Evidence map›Paper›PMID 34309709›Full record

ReviewParasitology research2021

Parasite protein phosphatases: biological function, virulence, and host immune evasion.

Jenny Nancy Gómez-Sandoval, Alma Reyna Escalona-Montaño, Abril Navarrete-Mena, M Magdalena Aguirre-García

Abstract readReview
PubMed Publisher
In one paragraph

Review in Parasitology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jenny Nancy Gómez-SandovalDivisión de Ingeniería en Biotecnología, Universidad Politécnica del Valle de Toluca, Estado de México, Carretera Toluca-Almoloya de Juárez km.5.6 Santiaguito Tlalcilalcali, Almoloya de Juárez, C.P. 50904, México.
Alma Reyna Escalona-MontañoDivisión de Investigación, Facultad de Medicina, Unidad de Investigación UNAM-INC, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano No. 1, Col. Sección XVI, Ciudad de México, C.P. 14080, Tlalpan, México.
Abril Navarrete-MenaDivisión de Investigación, Facultad de Medicina, Unidad de Investigación UNAM-INC, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano No. 1, Col. Sección XVI, Ciudad de México, C.P. 14080, Tlalpan, México.
M Magdalena Aguirre-GarcíaDivisión de Investigación, Facultad de Medicina, Unidad de Investigación UNAM-INC, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano No. 1, Col. Sección XVI, Ciudad de México, C.P. 14080, Tlalpan, México. maguirre@unam.mx.
Instituto Nacional de Cardiología · MXPolytechnic University of Puerto Rico · PR

Funding

DGAPA-PAPIIT IN218619SEP-CONACyT 284018
6 · The paper itself

Abstract

Protein phosphatases are enzymes that dephosphorylate tyrosine and serine/threonine amino acid residues. Although their role in cellular processes has been best characterized in higher eukaryotes, they have also been identified and studied in different pathogenic microorganisms (e.g., parasites) in the last two decades. Whereas some parasite protein phosphatases carry out functions similar to those of their homologs in yeast and mammalian cells, others have unique structural and/or functional characteristics. Thus, the latter unique phosphatases may be instrumental as targets for drug therapy or as markers for diagnosis. It is important to better understand the involvement of protein phosphatases in parasites in relation to their cell cycle, metabolism, virulence, and evasion of the host immune response. The up-to-date information about parasite phosphatases of medical and veterinarian relevance is herein reviewed.

Indexed as

Immune EvasionParasitesPhosphoprotein PhosphatasesAnimalsVirulencePhosphoprotein PhosphatasesFunctionParasitePhosphataseSerine/threonineTyrosineVirulence

Identifiers

PMID34309709
OpenAlexW3185691929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.