ArticleBiology of reproduction2021
Transcriptome and proteome dynamics of cervical remodeling in the mouse during pregnancy†.
Article in Biology of reproduction, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Effect of vaginal delivery history on oliceridine ED₅₀ combined with propofol during painless hysteroscopy: a modified Dixon sequential study.Frontiers in medicine · 2026Trial
- Type V Collagen Controls Decidual Extracellular Matrix Organization and Angiogenesis During Embryo Implantation.bioRxiv : the preprint server for biology · 2026Article
- Nitric oxide required for transition to slower hepatic protein synthesis rates during long-term caloric restriction.The Journal of clinical investigation · 2026Article
- Extracellular matrix reorganization during endometrial decidualization.Histochemistry and cell biology · 2025Article
- Collagen turnover during cervical remodeling involves both intracellular and extracellular collagen degradation pathways†.Biology of reproduction · 2025Article
- Article
- Cervical Collagen Network Porosity Assessed by SHG Endomicroscopy Distinguishes Preterm and Normal Pregnancy-A Pilot Study.IEEE transactions on bio-medical engineering · 2025Article
- Quantitative Assessment of Collagen Remodeling during a Murine Pregnancy.ACS photonics · 2024Article
- Equilibrium Mechanical Properties of the Nonhuman Primate Cervix.Journal of biomechanical engineering · 2024Article
- Uterine Collagen Cross-Linking: Biology, Role in Disorders, and Therapeutic Implications.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- The biomechanical evolution of the uterus and cervix and fetal growth in human pregnancy.npj women's health · 2024Article
- Molecular Landscape of Pelvic Organ Prolapse Provides Insights into Disease Etiology.International journal of molecular sciences · 2023Article
- Article
- Progesterone and its receptor signaling in cervical remodeling: Mechanisms of physiological actions and therapeutic implications.The Journal of steroid biochemistry and molecular biology · 2022Review
- Three-dimensional anisotropic hyperelastic constitutive model describing the mechanical response of human and mouse cervix.Acta biomaterialia · 2022Article
- Mechanical Response of Mouse Cervices Lacking Decorin and Biglycan During Pregnancy.Journal of biomechanical engineering · 2022Article
- Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ systems, differing mechanisms, and pathways.Frontiers in endocrinology · 2022Review
- Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy.Matrix biology : journal of the International Society for Matrix Biology · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
During gestation, the female reproductive tract must maintain pregnancy while concurrently preparing for parturition. Here, we explore the transitions in gene expression and protein turnover (fractional synthesis rates [FSR]) by which the cervix implements a transition from rigid to compliant. Shifts in gene transcription to achieve immune tolerance and alter epithelial cell programs begin in early pregnancy. Subsequently, in mid-to-late pregnancy transcriptional programs emerge that promote structural reorganization of the extracellular matrix (ECM). Stable isotope labeling revealed a striking slowdown of overall FSRs across the proteome on gestation day 6 that reverses in mid-to-late pregnancy. An exception was soluble fibrillar collagens and proteins of collagen assembly, which exhibit high turnover in nonpregnant cervix compared with other tissues and FSRs that continue throughout pregnancy. This finding provides a mechanism to explain how cross-linked collagen is replaced by newly synthesized, less cross-linked collagens, which allows increased tissue compliance during parturition. The rapid transition requires a reservoir of newly synthesized, less cross-linked collagens, which is assured by the high FSR of soluble collagens in the cervix. These findings suggest a previously unrecognized form of "metabolic flexibility" for ECM in the cervix that underlies rapid transformation in compliance to allow parturition.
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Registered trials
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