Activation by TyrR in Escherichia coli K-12 by Interaction between TyrR and the α-Subunit of RNA Polymerase.

Helen Camakaris, Ji Yang, Tadashi Fujii, James Pittard

Open access · greenAbstract read

In one paragraph

Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.7field-weighted citation impact, top 26% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

Deciphering the genetic background of an industrial 2-ketogluconic acid-producing strain Pseudomonas plecoglossicida JUIM01 using whole-genome sequencing.Biotechnology for biofuels and bioproducts · 2026
Article
AraC Functional Suppressors of Mutations in the C-Terminal Domain of the RpoA Subunit of theMicroorganisms · 2024
Article
Mutations in AcrR and RNA Polymerase Confer High-Level Resistance to Psoralen-UVA Irradiation.Journal of bacteriology · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Helen CamakarisSchool of Microbiology and Immunology, University of Melbournegrid.1008.9, Melbourne, Victoria, Australia.

Ji YangSchool of Microbiology and Immunology, University of Melbournegrid.1008.9, Melbourne, Victoria, Australia.

Tadashi FujiiMercian Corporation, Tokyo, Japan.

James PittardSchool of Microbiology and Immunology, University of Melbournegrid.1008.9, Melbourne, Victoria, Australia.

University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel selection was developed for mutants of the C-terminal domain of RpoA (α-CTD) altered in activation by the TyrR regulatory protein of Escherichia coli K-12. This allowed the identification of an aspartate to asparagine substitution at residue 250 (DN250) as an activation-defective (Act

Indexed as

Amino Acid SubstitutionDNA-Directed RNA PolymerasesEscherichia coli K12Escherichia coli ProteinsGene Expression Regulation, BacterialGene Expression Regulation, EnzymologicModels, MolecularMutagenesisMutationProtein ConformationRepressor ProteinsDNA-Directed RNA PolymerasesEscherichia coli ProteinsRepressor ProteinsRNA polymerase alpha subunitTyrR protein, E coliactivation and RpoAgene activationgene regulationRpoAtranscriptional controlTyrR

Identifiers

PMID34309399

DOI10.1128/JB.00252-21

PMCPMC8425403

OpenAlexW3183474643

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.