Evidence map›Paper›PMID 34309177›Full record

ArticleHIV medicine2021

Menopausal status, age and management among women living with HIV in the UK.

Hajra Okhai, Caroline A Sabin, Katharina Haag, Lorraine Sherr, Rageshri Dhairyawan, Fiona Burns, Richard Gilson, Frank Post, Jonathan Ross, Nicola Mackie and 7 more

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In one paragraph

Article in HIV medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hajra OkhaiInstitute for Global Health, University College London, London, UK.ORCID 0000-0002-0549-4914
Caroline A SabinInstitute for Global Health, University College London, London, UK.ORCID 0000-0001-5173-2760
Katharina HaagInstitute for Global Health, University College London, London, UK.
Lorraine SherrInstitute for Global Health, University College London, London, UK.
Rageshri DhairyawanDepartment of Infection and Immunity, Barts Health NHS Trust, London, UK.
Fiona BurnsInstitute for Global Health, University College London, London, UK.
Richard GilsonInstitute for Global Health, University College London, London, UK.
Frank PostKing's College Hospital NHS Foundation Trust, London, UK.ORCID 0000-0002-2844-1612
Jonathan RossUniversity Hospital Birmingham NHS Foundation Trust, Birmingham, UK.
Nicola MackieImperial College Healthcare NHS Trust, London, UK.
Ann SullivanChelsea and Westminster Healthcare NHS Foundation Trust, London, UK.
Jane ShepherdUK Community Advisory Board, London, UK.
Anjum TariqThe Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.
Rachael JonesChelsea and Westminster Healthcare NHS Foundation Trust, London, UK.
Julie FoxKing's College Hospital NHS Foundation Trust, London, UK.
Melanie RosenvingeLewisham and Greenwich NHS Trust, London, UK.
Shema TariqInstitute for Global Health, University College London, London, UK.

Funding

Department of Health PDF-2014-07-071Wellcome TrustWellcome Trust 204841/Z/16/Z
6 · The paper itself

Abstract

backgroundThere is currently little evidence exploring menopausal status, age at last menstrual period (LMP) and management of menopause among women living with HIV aged 45-60 years in England.

methodsSocio-demographic, lifestyle and clinical data were collected through a self-completed cross-sectional survey. Longitudinal CD4 count and viral load data were available from linkage to clinical records, if consent was provided. Women were categorised as pre-, peri- or post-menopausal. Factors associated with menopausal stage were examined using ordinal logistic regression adjusting for age. Age at LMP was estimated using Kaplan-Meier survival analysis.

resultsThe 847 women had a median age of 49 [interquartile range (IQR): 47-52] years. Most were of black ethnicity (81.3%), were born outside the UK (85.0%) and had completed secondary education (88.7%); 177 (20.4%), 373 (43.0%) and 297 (34.2%) were pre-, peri- or post-menopausal, respectively. After adjusting for age, associations of menopausal status with non-cohabiting relationship [adjusted odds ratio = 0.63 (95% confidence interval: 0.43-0.91)], baseline viral load ≥ 100 000 copies/mL [2.67 (1.20-5.94)] and unemployment [1.34 (0.97-1.84)] remained significant. Median (IQR) age at LMP was 54 (51-55) years in the group. In total, 27.9% (233/836) of women reported severe menopausal symptoms; 45.6% of those with somatic symptoms had heard of hormone replacement therapy and 8.7% had used it. Only 5.6% of women with urogenital symptoms had used topical oestrogen.

conclusionsOur findings highlight the importance of educating both women and their healthcare providers about menopausal symptoms and management options.

Indexed as

HIV InfectionsCross-Sectional StudiesFemaleHumansLife StyleMenopauseMiddle AgedUnited Kingdomageinghormone replacement therapymenopausesymptomswomen

Identifiers

PMID34309177
PMCPMC12086608

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