Evidence map›Paper›PMID 34309076›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2021

Programmable Mechanically Active Hydrogel-Based Materials.

Yixiao Dong, Allison N Ramey-Ward, Khalid Salaita

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Photo-guided azopolymer hydrogel actuators.Light, science & applications · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. An Opto-Actuated Hydrogel for Cell Mechanoactuation and Real-Time Force Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Review
  9. Hydrogel-based neural engineering for skin wound healing.Frontiers in cell and developmental biology · 2026
    Review
  10. Review
  11. Review
  12. Alginate Sphere-Based Soft Actuators.Gels (Basel, Switzerland) · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Hydrogel morphogenesis induced by force-controlled growth.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Tough Hydrogels for Load-Bearing Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yixiao DongDepartment of Chemistry, Emory University, Atlanta, GA, 30322, USA.ORCID https://orcid.org/0000-0001-8943-9842
Allison N Ramey-WardWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, 30332, USA.
Khalid SalaitaDepartment of Chemistry, Emory University, Atlanta, GA, 30322, USA.ORCID https://orcid.org/0000-0003-4138-3477

Funding

Catalytic Nanotherapies to Treat Lung DiseaseR01HL142866 · NHLBI · EMORY UNIVERSITY · PI SALAITA, KHALID S., WONGTRAKOOL, CHERRY P · 2018 to 2021
$1.7M
Molecular imaging technologies for mechanobiologyR01GM131099 · NIGMS · EMORY UNIVERSITY · PI MATTHEYSES, ALEXA LYNN, SALAITA, KHALID S. · 2019 to 2022
$1.6M
Developing a Bioanalytical Toolkit to Study the Mechanobiology of Juxtacrine SignalingR01GM124472 · NIGMS · EMORY UNIVERSITY · PI SALAITA, KHALID S. · 2017 to 2020
$1.5M
Rolosense: An innovative platform for automatic mobile phone readout of active SARS-CoV-2 particles (RADx-rad / SEED Administrative Supplement)U01AA029345 · NIAAA · EMORY UNIVERSITY · PI SALAITA, KHALID S. · 2021 to 2022
$1.4M
National Science Foundation 1905947NHLBI NIH HHS R01 HL142866NIAAA NIH HHS U01 AA029345NIGMS NIH HHS R01 GM124472NIGMS NIH HHS R01 GM131099NIH HHS R01 GM124472NIH HHS R01-GM124472NIH HHS R01 GM131099NIH HHS R01 HL142866NSF 1905947
6 · The paper itself

Abstract

Programmable mechanically active materials (MAMs) are defined as materials that can sense and transduce external stimuli into mechanical outputs or conversely that can detect mechanical stimuli and respond through an optical change or other change in the appearance of the material. Programmable MAMs are a subset of responsive materials and offer potential in next generation robotics and smart systems. This review specifically focuses on hydrogel-based MAMs because of their mechanical compliance, programmability, biocompatibility, and cost-efficiency. First, the composition of hydrogel MAMs along with the top-down and bottom-up approaches used for programming these materials are discussed. Next, the fundamental principles for engineering responsivity in MAMS, which includes optical, thermal, magnetic, electrical, chemical, and mechanical stimuli, are considered. Some advantages and disadvantages of different responsivities are compared. Then, to conclude, the emerging applications of hydrogel-based MAMs from recently published literature, as well as the future outlook of MAM studies, are summarized.

Indexed as

artificial musclesforce sensorsmechanical active materialsprogrammable hydrogel actuatorssmart skin

Identifiers

PMID34309076
PMCPMC8595730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.