Evidence map›Paper›PMID 34309006›Full record

Trial reportActa neurologica Scandinavica2021

EEG spindles integrity in critical care adults. Analysis of a randomized trial.

Paola Vassallo, Jan Novy, Frédéric Zubler, Kaspar Schindler, Vincent Alvarez, Stephan Rüegg, Andrea O Rossetti

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta neurologica Scandinavica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03129438 (Impact on Clinical Outcome of Continuous Video-electroencephalography), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03129438 nacompletednot on this map

Impact on Clinical Outcome of Continuous Video-electroencephalography (cEEG) Monitoring in Patients With Disorders of Consciousness: A Randomized Controlled Trial

TypeinterventionalSponsorAndrea Rossetti, MDRan2017 to 2019Enrolled404ConditionsEEG With Periodic Abnormalities, EEG With Abnormally Slow Frequencies, Coma, Outcome, FatalArmscontinuous EEG (cEEG), routine EEG (rEEG)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Paola VassalloDepartment of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-8758-9828
Jan NovyDepartment of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Frédéric ZublerSleep - Wake - Epilepsy - Center, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Kaspar SchindlerSleep - Wake - Epilepsy - Center, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Vincent AlvarezDepartment of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Stephan RüeggDepartment of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Andrea O RossettiDepartment of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-7878-172X
University of Lausanne · CHUniversity of Bern · CHHôpital du Valais · CHUniversity of Basel · CH

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 2017-00268
6 · The paper itself

Abstract

objectivesOccurrence of EEG spindles has been recently associated with favorable outcome in ICU patients. Available data mostly rely on relatively small patients' samples, particular etiologies, and limited variables ascertainment. We aimed to expand previous findings on a larger dataset, to identify clinical and EEG patterns correlated with spindle occurrence, and explore its prognostic implications.

methodsRetrospective observational study of prospectively collected data from a randomized trial (CERTA, NCT03129438) assessing the relationship of continuous (cEEG) versus repeated routine EEG (rEEG) with outcome in adults with acute consciousness impairment. Spindles were prospectively assessed visually as 12-16Hz activity on fronto-central midline regions, at any time during EEG interventions. Uni- and multivariable analyses explored correlations between spindles occurrence, clinical and EEG variables, and outcome (modified Rankin Scale, mRS; mortality) at 6 months.

resultsAmong the analyzed 364 patients, spindles were independently associated with EEG background reactivity (OR 13.2, 95% CI: 3.11-56.26), and cEEG recording (OR 4.35, 95% CI: 2.5 - 7.69). In the cEEG subgroup (n=182), 33.5% had spindles. They had better FOUR scores (p=0.004), fewer seizures or status epilepticus (p=0.02), and lower mRS (p=0.02). Mortality was reduced (p=0.002), and independently inversely associated with spindle occurrence (OR 0.50, CI 95% 0.25-0.99) and increased EEG background continuity (OR 0.16, 95% CI: 0.07 - 0.41).

conclusionsBesides confirming that spindle activity occurs in up to one third of acutely ill patients and is associated with better outcome, this study shows that cEEG has a higher yield than rEEG in identifying them. Furthermore, it unravels associations with several clinical and EEG features in this clinical setting.

Indexed as

ElectroencephalographyStatus EpilepticusAdultCritical CareHumansRetrospective StudiesSeizurescomacritical careoutcomespindles

Identifiers

PMID34309006
PMCPMC9290497
OpenAlexW3183639040

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.