ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021
[Ginsenoside Rh2 inhibits renal fibrosis and renal cell apoptosis in rats with diabetic nephropathy by downregulating discoid domain receptor 1].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Analysis of potential targets of 20S-protopanaxadiol on diabetic nephropathy based on network pharmacology, molecular docking, and experimental validation.Renal failure · 2025Article
- Renal function protection and the mechanism of ginsenosides: Current progress and future perspectives.Frontiers in pharmacology · 2023Review
- The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022Article
- Metabolite profiling and nephroprotective potential ofIranian journal of basic medical sciences · 2022Article
- Bioinformatics analysis of the potential regulatory mechanisms of renal fibrosis and the screening and identification of factors related to human renal fibrosis.Translational andrology and urology · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of ginsenoside Rh2 (G-Rh2) on renal fibrosis and cell apoptosis in rats with diabetic nephropathy (DN) and explore its possible mechanism.
methodsThirty male SD rats were randomized equally into control group, DN group and ginsenoside Rh2 intervention group. In the latter two groups, rat models of DN were established by intraperitoneal injection of streptozotocin, and the rats in the control group received injection of citrate buffer. After successful modeling, the rats in ginsenoside Rh2 intervention group were given ginsenoside Rh2 (20 mg · kg
resultsCompared with the control rats, the rat models of DN showed obvious renal fibrosis with an increased apoptosis index in the kidneys (
conclusionGinsenoside Rh2 inhibits renal fibrosis and renal cell apoptosis possibly in association with the down-regulation of DDR1 expression in the kidney of rat models of DN.
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