Evidence map›Paper›PMID 34308858›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021

[Balectin-3 affects the stability of vulnerable coronary atherosclerosis plaques by targeted modulation of lncARSR].

M Xu, L Li, W Li, J Liu, X Li, H Ye, J Chen, W Zou

Open access · greenAbstract read
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

M XuSanshui Hospital Affiliated to Guangdong Medical University, Foshan 528100, China.
L LiSanshui Hospital Affiliated to Guangdong Medical University, Foshan 528100, China.
W LiSanshui Hospital Affiliated to Guangdong Medical University, Foshan 528100, China.
J LiuSanshui Hospital Affiliated to Guangdong Medical University, Foshan 528100, China.
X LiSanshui Hospital Affiliated to Guangdong Medical University, Foshan 528100, China.
H YeSanshui Hospital Affiliated to Guangdong Medical University, Foshan 528100, China.
J ChenSanshui Hospital Affiliated to Guangdong Medical University, Foshan 528100, China.
W ZouSanshui Hospital Affiliated to Guangdong Medical University, Foshan 528100, China.
Foshan Hospital of TCM · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the mechanism by which galectin-3 (Gal-3) affects the stability of vulnerable coronary atherosclerosis plaques through long non-coding RNA ARSR (lncARSR).

methodMale BALB/c mice were randomly divided into normal diet group, high-fat diet group, high-fat diet+lncARSR inhibitor group (

resultsThe positively stained areas by Sudan IV and red oil O and the protein expression of lncARSR were the lowest in normal diet group and the highest in high-fat diet group (

conclusionGal-3 and lncARSR are overexpressed in coronary atherosclerosis. Through a mechanism for targeted inhibition of lncARSR, Gal-3 regulates the PI3K/ Akt signaling pathway to suppress inflammation and thus regulate the stability of vulnerable coronary atherosclerosis plaques.

Indexed as

Coronary Artery DiseasePlaque, AtheroscleroticRNA, Long NoncodingAnimalsDiet, High-FatMaleMiceMice, Inbred BALB CSignal TransductionRNA, Long Noncodingcoronary atherosclerosisgalectin-3lncARSRplaque stability

Identifiers

PMID34308858
PMCPMC8329687
OpenAlexW3205130985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.