Evidence map›Paper›PMID 34308839›Full record

ArticleeLife2021

Cdc4 phospho-degrons allow differential regulation of Ame1

Miriam Böhm, Kerstin Killinger, Alexander Dudziak, Pradeep Pant, Karolin Jänen, Simone Hohoff, Karl Mechtler, Mihkel Örd, Mart Loog, Elsa Sanchez-Garcia and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Miriam BöhmDepartment of Molecular Genetics I, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0002-6054-1912
Kerstin KillingerDepartment of Molecular Genetics I, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0002-1278-0302
Alexander DudziakDepartment of Molecular Genetics I, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0001-5082-3468
Pradeep PantDepartment of Computational Biochemistry, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0003-3890-1958
Karolin JänenDepartment of Molecular Genetics I, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany.
Simone HohoffDepartment of Molecular Genetics I, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany.
Karl MechtlerIMP - Research Institute of Molecular Pathology, Vienna, Austria.
Mihkel ÖrdInstitute of Technology, University of Tartu, Tartu, Estonia.
Mart LoogInstitute of Technology, University of Tartu, Tartu, Estonia.
Elsa Sanchez-GarciaDepartment of Computational Biochemistry, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0002-9211-5803
Stefan WestermannDepartment of Molecular Genetics I, Faculty of Biology, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0001-6921-9113
University of Duisburg-Essen · DEUniversity of Tartu · EEInstitute of Molecular Biotechnology · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kinetochores are multi-subunit protein assemblies that link chromosomes to microtubules of the mitotic and meiotic spindle. It is still poorly understood how efficient, centromere-dependent kinetochore assembly is accomplished from hundreds of individual protein building blocks in a cell cycle-dependent manner. Here, by combining comprehensive phosphorylation analysis of native Ctf19

Indexed as

Amino Acid SequenceCell Cycle ProteinsCell DivisionCentromereCytoskeletal ProteinsDNA-Binding ProteinsF-Box ProteinsKinetochoresMicrotubule-Associated ProteinsMutation, MissenseOrganisms, Genetically ModifiedPhosphorylationProtein StabilitySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSpindle ApparatusAme1 protein, S cerevisiaeCDC4 protein, S cerevisiaeCell Cycle ProteinsCTF19 protein, S cerevisiaeCytoskeletal ProteinsDNA-Binding ProteinsF-Box ProteinsMicrotubule-Associated ProteinsMTW1 protein, S cerevisiaeOkp1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsUbiquitin-Protein Ligasescell biologycell cyclechromosomesgene expressionkinetochoreS. cerevisiaeSCF

Identifiers

PMID34308839
PMCPMC8341979
OpenAlexW3186890841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.