ArticleJournal of the International Neuropsychological Society : JINS2021
Comparative Effects of Physical Exercise and Other Behavioral Interventions on Functional Status Outcomes in Mild Cognitive Impairment.
Article in Journal of the International Neuropsychological Society : JINS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Effects of dance therapy on cognitive and mental health in adults aged 55 years and older with mild cognitive impairment: a systematic review and meta-analysis.BMC geriatrics · 2023Pooled it
- Memory support training and lifestyle modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention (Brain Boosters).BMC geriatrics · 2023Trial
- Article
- Longitudinal neuropsychological evaluation allows diagnosis of MCI with less severe memory change.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- What clinicians could consider in providing group interventions for people with cognitive impairments: a scoping review.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2024Article
- Physical and cognitive function to explain the quality of life among older adults with cognitive impairment: exploring cognitive function as a mediator.BMC psychology · 2023Article
- Demand Coupling Drives Neurodegeneration: A Model of Age-Related Cognitive Decline and Dementia.Cells · 2022Review
- Behavioral Interventions in Mild Cognitive Impairment (MCI): Lessons from a Multicomponent Program.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Truly Cross-fit: The Association of Exercise and Clinical Outcomes: Introduction to a JINS Special Section.Journal of the International Neuropsychological Society : JINS · 2021Review
- Computerized Cognitive Training (CCT) versus Yoga Impact on 12 Month Post Intervention Cognitive Outcome in Individuals with Mild Cognitive Impairment.Brain sciences · 2021Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesLifestyle modifications for those with mild cognitive impairment (MCI) may promote functional stability, lesson disease severity, and improve well-being outcomes such as quality of life. The current analysis of our larger comparative effectiveness study evaluated which specific combinations of lifestyle modifications offered as part of the Mayo Clinic Healthy Action to Benefit Independence in Thinking (HABIT) program contributed to the least functional decline in people with MCI (pwMCI) over 18 months.
methodsWe undertook to compare evidence-based interventions with one another rather than to a no-treatment control group. The interventions were five behavioral treatments: computerized cognitive training (CCT), yoga, Memory Support System (MSS) training, peer support group (SG), and wellness education (WE), each delivered to both pwMCI and care partners, in a group-based program. To compare interventions, we randomly withheld one of the five HABIT® interventions in each of the group sessions. We conducted 24 group sessions with between 8 and 20 pwMCI-partner dyads in a session.
resultsWithholding yoga led to the greatest declines in functional ability as measured by the Functional Activities Questionnaire and Clinical Dementia Rating. In addition, memory compensation (calendar) training and cognitive exercise appeared to have associations (moderate effect sizes) with better functional outcomes. Withholding SG or WE appeared to have little effect on functioning at 18 months.
conclusionsOverall, these results add to the growing literature that physical exercise can play a significant and lasting role in modifying outcomes in a host of medical conditions, including neurodegenerative diseases.
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