Evidence map›Paper›PMID 34308697›Full record

ArticleGlobal spine journal2023

Correlation Between the Spinal Instability Neoplastic Score (SINS) and Patient Reported Outcomes.

Anne L Versteeg, Arjun Sahgal, Ilya Laufer, Laurence D Rhines, Daniel M Sciubba, James M Schuster, Michael H Weber, Aron Lazary, Stefano Boriani, Chetan Bettegowda and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global spine journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 4 countries.

Anne L VersteegDivision of Surgery, Department of Orthopaedic Surgery, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-3251-9694
Arjun SahgalDepartment of Radiation Oncology, Sunnybrook Odette Cancer Centre and University of Toronto, Toronto, Ontario, Canada.
Ilya LauferDivision of Spinal Neurosurgery, Department of Neurosurgery, NYU Langone Langone Health, New York, NY, USA.
Laurence D RhinesDepartment of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Daniel M SciubbaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-7604-434X
James M SchusterDepartment of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Michael H WeberDivision of Surgery, McGill University and Montreal General Hospital, Montreal, Quebec, Canada.
Aron LazaryNational Center for Spinal Disorders and Buda Health Center, Budapest, Hungary.ORCID 0000-0002-0157-719X
Stefano BorianiGSpine4 Spine Surgery Division, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Chetan BettegowdaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael G FehlingsDivision of Neurosurgery and Spine Program, University of Toronto and Toronto Western Hospital, Toronto, Ontario, Canada.ORCID 0000-0002-5722-6364
Michelle J ClarkeDepartment of Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Paul M ArnoldDepartment of Neurosurgery, Carle Foundation Hospital, Urbana, IL, USA.ORCID 0000-0002-4622-7695
Ziya L GokaslanDepartment of Neurosurgery, The Warren Alpert Medical School of Brown University and Rhode Island Hospital and The Miriam Hospital, Providence, RI, USA.
Charles G FisherDivision of Spine, Department of Orthopaedics, University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada.
AO Spine Knowledge Forum TumorResearch Department, AO Spine International, Davos, Switzerland.
Johns Hopkins University · USUniversity of Toronto · CABrown University · USBuda Health Center · HUCarle Foundation Hospital · USHospital of the University of Pennsylvania · USIstituto Ortopedico Galeazzi · ITMayo Clinic in Arizona · USMontreal General Hospital · CANYU Langone Health · USSunnybrook Health Science Centre · CAThe University of Texas MD Anderson Cancer Center · USUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designInternational multicenter prospective observational cohort study on patients undergoing radiation +/- surgical intervention for the treatment of symptomatic spinal metastases.

objectivesTo investigate the association between the total Spinal Instability Neoplastic Score (SINS), individual SINS components and PROs.

methodsData regarding patient demographics, diagnostics, treatment, and PROs (SF-36, SOSGOQ, EQ-5D) was collected at baseline, 6 weeks, and 12 weeks post-treatment. The SINS was assessed using routine diagnostic imaging. The association between SINS, PRO at baseline and change in PROs was examined with the Spearmans rank test.

resultsA total of 307 patients, including 174 patients who underwent surgery+/- radiotherapy and 133 patients who underwent radiotherapy were eligible for analyses. In the surgery+/- radiotherapy group, 18 (10.3%) patients with SINS score between 0-6, 118 (67.8%) with a SINS between 7-12 and 38 (21.8%) with a SINS between 13-18, as compared to 55 (41.4%) SINS 0-6, 71(53.4%) SINS 7-12 and 7 (5.2%) SINS 13-18 in the radiotherapy alone group. At baseline, the total SINS and the presence of mechanical pain was significantly associated with the SOSGOQ pain domain (r = -0.519,

conclusionSpinal instability, as defined by the SINS, was significantly correlated with PROs at baseline and change in PROs post-treatment. Mechanical pain, as a single SINS component, showed the highest correlations with PROs.

Indexed as

patient reported outcomesspinal instabilityspinal metastases

Identifiers

PMID34308697
PMCPMC10416601
OpenAlexW3186363744

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.