Evidence map›Paper›PMID 34308665›Full record

ArticleCartilage2021

Cartilage Repair Capacity within a Single Full-Thickness Chondral Defect in a Porcine Autologous Matrix-Induced Chondrogenesis Model Is Affected by the Location within the Defect.

E Salonius, A Meller, T Paatela, A Vasara, J Puhakka, M Hannula, A-M Haaparanta, I Kiviranta, V Muhonen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Enhancing the Reliability of Cartilage Repair Evaluation: A Simplified Volume-Based Approach.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

E SaloniusDepartment of Orthopaedics and Traumatology, Clinicum, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-1988-2800
A MellerUniversity of Helsinki, HiLIFE-Helsinki Institute of Life Science Laboratory Animal Center, Helsinki, Finland.
T PaatelaDepartment of Orthopaedics and Traumatology, Clinicum, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-6389-051X
A VasaraDepartment of Orthopaedics and Traumatology, Clinicum, University of Helsinki, Helsinki, Finland.
J PuhakkaDepartment of Orthopaedics and Traumatology, Clinicum, University of Helsinki, Helsinki, Finland.
M HannulaDepartment of Electronics and Communications Engineering, Tampere University of Technology, BioMediTech, Institute of Biosciences and Medical Technology, Tampere, Pirkanmaa, Finland.
A-M HaaparantaDepartment of Electronics and Communications Engineering, Tampere University of Technology, BioMediTech, Institute of Biosciences and Medical Technology, Tampere, Pirkanmaa, Finland.
I KivirantaDepartment of Orthopaedics and Traumatology, Clinicum, University of Helsinki, Helsinki, Finland.
V MuhonenDepartment of Orthopaedics and Traumatology, Clinicum, University of Helsinki, Helsinki, Finland.
University of Helsinki · FITampere University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLarge articular cartilage defects are a challenge to regenerative surgery. Biomaterial scaffolds might provide valuable support for restoration of articulating surface. The performance of a composite biomaterial scaffold was evaluated in a large porcine cartilage defect.

designCartilage repair capacity of a biomaterial combining recombinant human type III collagen (rhCo) and poly-(l/d)-lactide (PLA) was tested in a porcine model. A full-thickness chondral defect covering the majority of the weightbearing area was inflicted to the medial femoral condyle of the right knee. Spontaneous cartilage repair and nonoperated healthy animals served as controls. The animals were sacrificed after a 4-month follow-up. The repair tissue was evaluated with the International Cartilage Repair Society (ICRS) macroscopic score, ICRS II histological score, and with micro-computed tomography. Additionally, histopathological evaluation of lymph nodes and synovial samples were done for toxicological analyses.

resultsThe lateral half of the cartilage defect in the operated groups showed better filling than the medial half. The mean overall macroscopic score for the rhCo-PLA, spontaneous, and nonoperated groups were 5.96 ± 0.33, 4.63 ± 0.42, and 10.98 ± 0.35, respectively. The overall histological appearance of the specimens was predominantly hyaline cartilage in 3 of 9 samples of the rhCo-PLA group, 2 of 8 of the spontaneous group, and 9 of 9 of the nonoperated group.

conclusionsThe use of rhCo-PLA scaffold did not differ from spontaneous healing. The repair was affected by the spatial properties within the defect, as the lateral part of the defect showed better repair than the medial part, probably due to different weightbearing conditions.

Indexed as

Cartilage, ArticularCartilage DiseasesAnimalsChondrogenesisSwineTransplantation, AutologousX-Ray Microtomographyanimal modelbiomaterialcartilage repair

Identifiers

PMID34308665
PMCPMC8804745
OpenAlexW3183500215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.