Evidence map›Paper›PMID 34308630›Full record

ArticleJournal of the American Chemical Society2021

Sensitivity-Enhanced Solid-State NMR Detection of Structural Differences and Unique Polymorphs in Pico- to Nanomolar Amounts of Brain-Derived and Synthetic 42-Residue Amyloid-β Fibrils.

Ayesha Wickramasinghe, Yiling Xiao, Naohiro Kobayashi, Songlin Wang, Kathryn P Scherpelz, Toshio Yamazaki, Stephen C Meredith, Yoshitaka Ishii

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

  1. Breaking theACS measurement science au · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Structural characterization of E22G AβPhysical chemistry chemical physics : PCCP · 2024
    Article
  8. Article
  9. Article
  10. Structural polymorphism and cytotoxicity of brain-derived β-amyloid extracts.Protein science : a publication of the Protein Society · 2023
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Chemical reviews · 2022
    Review
  16. Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ayesha WickramasingheSchool of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Yiling XiaoDepartment of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607, United States.
Naohiro KobayashiNMR Division, RIKEN SPring-8 Center, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Songlin WangDepartment of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607, United States.
Kathryn P ScherpelzDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States.
Toshio YamazakiNMR Division, RIKEN SPring-8 Center, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Stephen C MeredithDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0002-8427-7466
Yoshitaka IshiiSchool of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.ORCID 0000-0002-7724-6469
NHK Spring (Japan) · JPTokyo Institute of Technology · JPUniversity of Chicago · USUniversity of Illinois Chicago · US

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
Alzheimer's Brain-Seeded Abeta FibrilsR01AG048793 · NIA · UNIVERSITY OF CHICAGO · PI MEREDITH, STEPHEN C. · 2015 to 2019
$2.1M
Structures and Propagation of Pathologically Relevant Amyloids in Alzheimer's.U01GM098033 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ISHII, YOSHITAKA · 2016 to 2020
$1.3M
Human vs. Rodent Amyloid-beta FibrilsR21AG067036 · NIA · UNIVERSITY OF CHICAGO · PI MEREDITH, STEPHEN C. · 2020 to 2020
$446k
NIA NIH HHS R01 AG048793NIA NIH HHS R21 AG067036NIGMS NIH HHS T32 GM007281NIGMS NIH HHS U01 GM098033
6 · The paper itself

Abstract

Amyloid-β (Aβ) fibrils in neuritic plaques are a hallmark of Alzheimer's disease (AD). Since the 42-residue Aβ (Aβ42) fibril is the most pathogenic among different Aβ species, its structural characterization is crucial to our understanding of AD. While several polymorphs have been reported for Aβ40, previous studies of Aβ42 fibrils prepared at neutral pH detected essentially only one structure, with an S-shaped β-sheet arrangement (

Indexed as

Nuclear Magnetic Resonance, BiomolecularAmyloid beta-PeptidesBrainHumansProtein ConformationProteinsAmyloid beta-PeptidesProteins

Identifiers

PMID34308630
PMCPMC10279877
OpenAlexW3185916358

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.