SynthesisBrain imaging and behavior2022
The accumulation of subconcussive impacts on cognitive, imaging, and biomarker outcomes in child and college-aged athletes: a systematic review.
Synthesis in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Repetitive Head Impacts During Contact Sports and Fluid Biomarkers of Neural Damage: A Meta-analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Youth Soccer Participation and Brain Health Outcomes in Adolescent Athletes.JAMA network open · 2026Article
- Living with the aftermath: family experiences of managing concussion and sport-related head injury.Frontiers in sports and active living · 2026Article
- Article
- Memory outcomes and interventions after sports-related traumatic brain injuries in pediatric and young adult athletes: a scoping review.Journal of pediatric psychology · 2025Article
- Delaying Tackling in Youth Contact Sports: Moving toward a Safer Future or Softening the Game?Sports medicine (Auckland, N.Z.) · 2025Article
- Associations Between Brain Metabolites Measured With MR Spectroscopy and Head Impacts in High School American Football Athletes.Journal of magnetic resonance imaging : JMRI · 2025Article
- Concussion injuries in sports and the role of instrumented mouthguards: a mini review.Frontiers in bioengineering and biotechnology · 2025Review
- American Football On-Field Head Impact Kinematics: Influence of Acceleration Signal Characteristics on Peak Maximal Principal Strain.Annals of biomedical engineering · 2024Article
- Head Kinematics and Injury Analysis in Elite Bobsleigh Athletes Throughout a World Cup Tour.Journal of athletic training · 2024Article
- The Use of Biofluid Markers to Evaluate the Consequences of Sport-Related Subconcussive Head Impact Exposure: A Scoping Review.Sports medicine - open · 2024Article
- Elevated Autoantibodies to the GluA1 Subunit of the AMPA Receptor in Blood Indicate Risk of Cognitive Impairment in Contact Sports Athletes, Irrespective of Concussion.Neurotrauma reports · 2024Article
- Amyloid PET across the cognitive spectrum in former professional and college American football players: findings from the DIAGNOSE CTE Research Project.Alzheimer's research & therapy · 2023Article
- High School Football and Risk for Depression and Suicidality in Adulthood: Findings From a National Longitudinal Study.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Examine the effect of subconcussive impact accumulation on cognitive/functional, imaging, and biomarker outcomes over the course of a single season, specifically in contact sport athletes at collegiate level or younger. Systematic review following PRISMA guidelines and using Oxford Center for Evidence-Based Medicine 2011 Levels of Evidence and Newcastle Ottawa Assessment Scale. PubMed MEDLINE, PsycInfo, SPORT-Discus, Web of Science. Original research in English that addressed the influence of subconcussive impacts on outcomes of interest with minimum preseason and postseason measurement in current youth, high school, or college-aged contact sport athletes. 796 articles were initially identified, and 48 articles were included in this review. The studies mostly involved male football athletes in high school or college and demonstrated an underrepresentation of female and youth studies. Additionally, operationalization of previous concussion history and concussion among studies was very inconsistent. Major methodological differences existed across studies, with ImPACT and diffusion tensor imaging being the most commonly used modalities. Biomarker studies generally showed negative effects, cognitive/functional studies mostly revealed no effects, and advanced imaging studies showed generally negative findings over the season; however, there was variability in the findings across all types of studies. This systematic review revealed growing literature on this topic, but inconsistent methodology and operationalization across studies makes it challenging to draw concrete conclusions. Overall, cognitive measures alone do not seem to detect changes across this timeframe while imaging and biomarker measures may be more sensitive to changes following subconcussive impacts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.