ArticleJournal of the Egyptian National Cancer Institute2021
Green tea catechins in combination with irinotecan attenuates tumorigenesis and treatment-associated toxicity in an inflammation-associated colon cancer mice model.
Article in Journal of the Egyptian National Cancer Institute, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 16 citations in OpenAlex.
- Epigallocatechin-3-Gallate, the green tea polyphenol suppresses expression of CD31 and VEGFR2 and enhances the chemotherapeutic potential of irinotecan in AOM/DSS model of colorectal cancer in mice.Journal of the Egyptian National Cancer Institute · 2026Article
- Thapsigargin enhanced chemotherapeutic sensitivity of irinotecan in the inflammation-induced colorectal cancer model in mice.Scientific reports · 2026Article
- Sarco/endoplasmic reticulum calcium ATPase expression in AOM/DSS model of colon carcinogenesis in mice.Histochemistry and cell biology · 2025Article
- Green Tea Components: In Vitro and In Vivo Evidence for Their Anticancer Potential in Colon Cancer.Cancers · 2025Review
- Epigallocatechin-3-gallate inhibits the formation of neutrophil extracellular traps and suppresses the migration and invasion of colon cancer cells by regulating STAT3/CXCL8 pathway.Molecular and cellular biochemistry · 2023Article
- Natural Polyphenols for Treatment of Colorectal Cancer.Molecules (Basel, Switzerland) · 2022Review
- Anticarcinogenic potentials of tea catechins.Frontiers in nutrition · 2022Review
- Phytochemicals in Cancer Chemoprevention: Preclinical and Clinical Studies.Cancer control : journal of the Moffitt Cancer CenterReview
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2 authors at 1 institution in 1 country.
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Abstract
backgroundAdministration of green tea (GT) catechins has been reported to ensue antitumor activity in combination with chemotherapeutic drugs against different cancer types. Irinotecan (IRN) is a highly effective chemotherapeutic drug against various types of cancer including colon cancer along with its analogous dose-limiting side effects viz. diarrhea, neutropenia, leucopenia, and non-alcoholic fatty liver disease (NAFLD) as major toxicities.
methodsIn this study, we investigated the antitumor effects of GT alone or in combination with IRN in inflammation-associated colon cancer mouse model induced by azoxymethane (AOM) and dextran sulfate sodium (DSS). We also evaluated the effect of GT- on IRN-induced toxicity and histopathological alterations. Animals were divided into six groups (n = 5 per group). After induction of cancer model, animals were treated with GT and/or IRN. We observed the inflammation, tumor progression, and ameliorative effects of GT and IRN alone or in combination.
resultsBecause of antioxidant potential of GT, IRN-induced toxicity ameliorative effect of GT was also studied in combined treated groups. It was found that co-administration of IRN and GT significantly decreased number of tumors and simultaneously was found to ameliorate diarrhea along with leucopenia and neutropenia. Besides these, mitigation of adenomatous characters and NAFLD was also observed in the IRN- and GT-treated group when analyzed histologically.
conclusionsGT significantly reduced the toxicity induced by IRN in terms of diarrhea, neutropenia, leucopenia, and NAFLD and works as an effective anticancer agent as it mitigates histopathology of colon adenocarcinoma.
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