Evidence map›Paper›PMID 34308497›Full record

ReviewCurrent atherosclerosis reports2021

Social Determinants of Health and Cardiovascular Disease: Current State and Future Directions Towards Healthcare Equity.

Mohammad Hashim Jilani, Zulqarnain Javed, Tamer Yahya, Javier Valero-Elizondo, Safi U Khan, Bita Kash, Ron Blankstein, Salim S Virani, Michael J Blaha, Prachi Dubey and 4 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current atherosclerosis reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. A Systematic Review of Cardiovascular Health Among Cancer Survivors.International journal of environmental research and public health · 2025
    Pooled it
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  4. Life Course Assessment of Area-Based Social Disadvantage: A Systematic Review.International journal of environmental research and public health · 2023
    Pooled it
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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mohammad Hashim Jilani *Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Zulqarnain Javed *Division of Cardiovascular Prevention and Wellness, Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA.
Tamer YahyaDivision of Cardiovascular Prevention and Wellness, Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA.
Javier Valero-ElizondoDivision of Cardiovascular Prevention and Wellness, Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA.
Safi U KhanDepartment of Medicine, West Virginia University, Morgantown, WV, USA.
Bita KashDivision of Health Equity & Disparities Research, Center for Outcomes Research, Houston Methodist, Houston, TX, USA.
Ron BlanksteinCardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
Salim S ViraniMichael E. DeBakey Veterans Affair Medical Center, Houston, TX, USA.
Michael J BlahaCiccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University, Baltimore, MD, USA.
Prachi DubeyHouston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.
Adnan A HyderMilken Institute School of Public Health, George Washington University, Washington, DC, USA.
Farhaan S VahidyDivision of Health Equity & Disparities Research, Center for Outcomes Research, Houston Methodist, Houston, TX, USA.
Miguel Cainzos-AchiricaDivision of Cardiovascular Prevention and Wellness, Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA.
Khurram NasirDivision of Cardiovascular Prevention and Wellness, Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA. knasir@houstonmethodist.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewWe sought to examine the role of social and environmental conditions that determine an individual's behaviors and risk of disease-collectively known as social determinants of health (SDOH)-in shaping cardiovascular (CV) health of the population and giving rise to disparities in risk factors, outcomes, and clinical care for cardiovascular disease (CVD), the leading cause of death in the United States (US). RECENT

findingsTraditional CV risk factors have been extensively targeted in existing CVD prevention and management paradigms, often with little attention to SDOH. Limited evidence suggests an association between individual SDOH (e.g., income, education) and CVD. However, inequities in CVD care, risk factors, and outcomes have not been studied using a broad SDOH framework. We examined existing evidence of the association between SDOH-organized into 6 domains, including economic stability, education, food, neighborhood and physical environment, healthcare system, and community and social context-and CVD. Greater social adversity, defined by adverse SDOH, was linked to higher burden of CVD risk factors and poor outcomes, such as stroke, myocardial infarction (MI), coronary heart disease, heart failure, and mortality. Conversely, favorable social conditions had protective effects on CVD. Upstream SDOH interact across domains to produce cumulative downstream effects on CV health, via multiple physiologic and behavioral pathways. SDOH are major drivers of sociodemographic disparities in CVD, with a disproportionate impact on socially disadvantaged populations. Efforts to achieve health equity should take into account the structural, institutional, and environmental barriers to optimum CV health in marginalized populations. In this review, we highlight major knowledge gaps for each SDOH domain and propose a set of actionable recommendations to inform CVD care, ensure equitable distribution of healthcare resources, and reduce observed disparities.

Indexed as

Cardiovascular DiseasesHeart FailureDelivery of Health CareHumansRisk FactorsSocial Determinants of HealthUnited StatesCardiovascular diseaseHealth disparitiesSocial determinants of health

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.