Evidence map›Paper›PMID 34308496›Full record

ArticleIntensive care medicine experimental2021

Effect of positive end-expiratory pressure on additional passive ventilation generated by CPR compressions in a porcine model.

Yosef Levenbrown, Md Jobayer Hossain, James P Keith, Katlyn Burr, Anne Hesek, Thomas H Shaffer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yosef LevenbrownDivision of Pediatric Critical Care, Nemours/Alfred I. duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE, 19803, USA. yoseflevenbrown@gmail.com.ORCID http://orcid.org/0000-0002-9541-2301
Md Jobayer HossainNemours Biomedical Research, Wilmington, DE, USA.
James P KeithDepartment of Respiratory Care, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.
Katlyn BurrDepartment of Respiratory Care, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.
Anne HesekNemours Biomedical Research, Wilmington, DE, USA.
Thomas H ShafferDepartment of Pediatrics, Sidney Kimmel Medical School of Thomas Jefferson University, Philadelphia, PA, USA.
Alfred I. duPont Hospital for Children · USDuPont (United States) · USThomas Jefferson University · US

Funding

Center for Pediatric Research Pilot ProgramP30GM114736 · NIGMS · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI SHAFFER, THOMAS H · 2015 to 2019
$5.1M
National Institutes of Health (US) P30GM114736NIGMS NIH HHS P30 GM114736
6 · The paper itself

Abstract

backgroundCompressions given during cardiopulmonary resuscitation generate small, ineffective passive ventilations through oscillating waves. Positive end-expiratory pressure increases the volume of these passive ventilations; however, its effect on passive ventilation is unknown. Our objective was to determine if increasing positive end-expiratory pressure during cardiopulmonary resuscitation increases passive ventilation generated by compressions to a clinically significant point. This study was conducted on 13 Landrace-Yorkshire pigs. After inducing cardiac arrest with bupivacaine, cardiopulmonary resuscitation was performed with a LUCAS 3.1. During cardiopulmonary resuscitation, pigs were ventilated at a positive end-expiratory pressure of 0, 5, 10, 15, 20 cmH

resultsIncreasing positive end-expiratory pressure from 0 to 20 cmH

conclusionsWhen increasing positive end-expiratory pressure from 0 to 20, the contribution to overall ventilation from gas oscillations generated by the compressions became more significant, and may even lead to hypocapnia, especially when using positive end-expiratory pressures between 15 and 20.

Indexed as

Cardiac arrestCompressionsResuscitationTidal volumeVentilation

Identifiers

PMID34308496
PMCPMC8310691
OpenAlexW3186663221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.