Evidence map›Paper›PMID 34308420›Full record

ArticleJournal of experimental neurology2021

Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome.

Shu-Hui Chuang, Ruth E Westenbroek, Nephi Stella, William A Catterall

Open access · hybridAbstract read
In one paragraph

Article in Journal of experimental neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shu-Hui ChuangDepartment of Pharmacology, University of Washington, Seattle, Washington 98195, USA.
Ruth E WestenbroekDepartment of Pharmacology, University of Washington, Seattle, Washington 98195, USA.
Nephi StellaDepartment of Pharmacology, University of Washington, Seattle, Washington 98195, USA.
William A CatterallDepartment of Pharmacology, University of Washington, Seattle, Washington 98195, USA.
University of Washington · US

Funding

Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9M
Sodium and Calcium Channels: Structure, Function, Neuroplasticity, and DiseaseR35NS111573 · NINDS · UNIVERSITY OF WASHINGTON · PI SCOTT, JOHN D · 2019 to 2024
$6.1M
NICHD NIH HHS P50 HD103524NINDS NIH HHS R35 NS111573
6 · The paper itself

Abstract

Dravet Syndrome (DS) is a severe childhood epilepsy caused by heterozygous loss-of-function mutations in the

Indexed as

BenzodiazepinesCannabidiolCombination therapyDravet syndromeFebrile seizuresNav1.1Scn1a

Identifiers

PMID34308420
PMCPMC8301289
OpenAlexW3174367010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.