ArticleThe Lancet regional health. Europe2021
SARS-CoV-2 seroprevalence in a strictly-Orthodox Jewish community in the UK: A retrospective cohort study.
Article in The Lancet regional health. Europe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Barriers and enablers to vaccination in the ultra-orthodox Jewish population: a systematic review.Frontiers in public health · 2023Pooled it
- Qualitative evaluation of two London Faith and Health Networks: lessons learnt from a model of an interface between health systems and minority communities.BMJ public health · 2025Article
- SARS-CoV-2 Seroprevalence Trends in the Netherlands in the Variant of Concern Era: Input for Future Response.Influenza and other respiratory viruses · 2024Article
- Article
- Tailoring immunisation programmes in a time of SARS-CoV-2: What can be learnt by comparing the findings of childhood and COVID-19 vaccine evaluation studies in an underserved population?Public health in practice (Oxford, England) · 2022Article
- Seroconversion rate and socio-economic and ethnic risk factors for SARS-CoV-2 infection in children in a population-based cohort, Germany, June 2020 to February 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022Observational
- "We've all got the virus inside us now": Disaggregating public health relations and responsibilities for health protection in pandemic London.Social science & medicine (1982) · 2022Article
- Antibody-Mediated Immunogenicity Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Following Priming, Boosting, and Hybrid Immunity: Insights From 11 Months of Follow-up of a Healthcare Worker Cohort in Israel, December 2020-October 2021.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Is stronger religious faith associated with a greater willingness to take the COVID-19 vaccine? Evidence from Israel and Japan.The European journal of health economics : HEPAC : health economics in prevention and care · 2022Article
- Transmission dynamics of SARS-CoV-2 in a strictly-Orthodox Jewish community in the UK.Scientific reports · 2022Article
- Article
- Low COVID-19 vaccine coverage and other COVID-19 risk factors of Ultra-Orthodox jews.QJM : monthly journal of the Association of Physicians · 2022Article
- Quantifying previous SARS-CoV-2 infection through mixture modelling of antibody levels.Nature communications · 2021Article
- Racial differences in anticipated COVID-19 vaccine acceptance among religious populations in the US.Vaccine · 2021Article
- "If a rabbi did say 'you have to vaccinate,' we wouldn't": Unveiling the secular logics of religious exemption and opposition to vaccination.Social science & medicine (1982) · 2021Article
- Incorporating false negative tests in epidemiological models for SARS-CoV-2 transmission and reconciling with seroprevalence estimates.Scientific reports · 2021Article
- Understanding how communities respond to COVID-19: experiences from the Orthodox Jewish communities of Antwerp city.International journal for equity in health · 2021Article
- Elevated Jewish Mortality from Coronavirus in England and Wales: An Epidemiological and Demographic Detective Story.Contemporary Jewry · 2021Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundEthnic and religious minorities have been disproportionately affected by SARS-CoV-2 worldwide. The UK strictly-Orthodox Jewish community has been severely affected by the pandemic. This group shares characteristics with other ethnic minorities including larger family sizes, higher rates of household crowding and relative socioeconomic deprivation. We studied a UK strictly-Orthodox Jewish population to understand transmission of COVID-19 within this community.
methodsWe performed a household-focused cross-sectional SARS-CoV-2 serosurvey between late-October and early December 2020 prior to the third national lockdown. Randomly-selected households completed a standardised questionnaire and underwent serological testing with a multiplex assay for SARS-CoV-2 IgG antibodies. We report clinical illness and testing before the serosurvey, seroprevalence stratified by age and sex. We used random-effects models to identify factors associated with infection and antibody titres.
findingsA total of 343 households, consisting of 1,759 individuals, were recruited. Serum was available for 1,242 participants. The overall seroprevalence for SARS-CoV-2 was 64.3% (95% CI 61.6-67.0%). The lowest seroprevalence was 27.6% in children under 5 years and rose to 73.8% in secondary school children and 74% in adults. Antibody titres were higher in symptomatic individuals and declined over time since reported COVID-19 symptoms, with the decline more marked for nucleocapsid titres.
interpretationIn this tight-knit religious minority population in the UK, we report one of the highest SARS-CoV-2 seroprevalence levels in the world to date, which was markedly higher than the reported 10% seroprevalence in London at the time of the study. In the context of this high force of infection, all age groups experienced a high burden of infection. Actions to reduce the burden of disease in this and other minority populations are urgently required.
fundingThis work was jointly funded by UKRI and NIHR [COV0335; MR/V027956/1], a donation from the LSHTM Alumni COVID-19 response fund, HDR UK, the MRC and the Wellcome Trust.
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