Evidence map›Paper›PMID 34308364›Full record

ArticleFood frontiers2020

Transplanting fecal material from wild-type mice fed black raspberries alters the immune system of recipient mice.

Yi-Wen Huang, Pan Pan, Carla Elena Echeveste, Hsin-Tzu Wang, Kiyoko Oshima, Chien-Wei Lin, Martha Yearsley, Jianbo Xiao, Jiebiao Chen, Chongde Sun and 2 more

Open access · goldAbstract read
In one paragraph

Article in Food frontiers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Antioxidative and Immunomodulating Properties ofPlants (Basel, Switzerland) · 2022
    Article
  4. Antidiabetic potential of polysaccharides fromCurrent research in food science · 2022
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Yi-Wen HuangDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Wauwatosa, Wisconsin.
Pan PanDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Wauwatosa, Wisconsin.
Carla Elena EchevesteDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Wauwatosa, Wisconsin.
Hsin-Tzu WangDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Wauwatosa, Wisconsin.
Kiyoko OshimaDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Chien-Wei LinDivision of Biostatistics, Medical College of Wisconsin, Wauwatosa, Wisconsin.ORCID 0000-0003-4023-7339
Martha YearsleyDepartment of Pathology, The Ohio State University, Columbus, Ohio.
Jianbo XiaoInstitute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau, China.ORCID 0000-0003-3311-770X
Jiebiao ChenLaboratory of Fruit Quality Biology/Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou, China.
Chongde SunLaboratory of Fruit Quality Biology/Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou, China.
Jianhua YuDepartment of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, California.
Li-Shu WangDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Wauwatosa, Wisconsin.
Medical College of Wisconsin · USMinistry of Agriculture · IDCity Of Hope National Medical Center · USJohns Hopkins University · USThe Ohio State University · USUniversity of Macau · MO

Funding

Elucidate and Modulate Cell Signaling in NK Cells for Glioma TreatmentR01AI129582 · NIAID · OHIO STATE UNIVERSITY · PI YU, JIANHUA · 2017 to 2021
$2.1M
Overcoming Barriers of Virotherapy by Next-Generation oHSV Expressing E-CadherinR01NS106170 · NINDS · OHIO STATE UNIVERSITY · PI YU, JIANHUA · 2018 to 2023
$1.9M
Enhancing NK Cell Activity by Dietary Diphyllin Lignans for Cancer PreventionR01CA185301 · NCI · OHIO STATE UNIVERSITY · PI CALIGIURI, MICHAEL A, YU, JIANHUA · 2015 to 2019
$1.8M
Mechanisms of tumor suppressor gene reactivation in colon cancer by berriesR01CA148818 · NCI · OHIO STATE UNIVERSITY · PI WANG, LI-SHU · 2010 to 2014
$1.5M
NCI NIH HHS R01 CA148818NCI NIH HHS R01 CA185301NIAID NIH HHS R01 AI129582NINDS NIH HHS R01 NS106170
6 · The paper itself

Abstract

By constantly stimulating intestinal immunity, gut microbes play important regulatory roles, and their possible involvement in human physical and mental disorders beyond intestinal diseases suggests the importance of maintaining homeostasis in the gut microbiota. Both transplantation of fecal microbiota and dietary interventions have been shown to restore microbial homeostasis in recipients. In the current study with wild-type mice, we combined these two approaches to determine if transplanting fecal material from mice fed black raspberries (BRB, 5%) altered recipients' immune system. The donors received a control or 5% BRB diet, and fecal transplantation was performed every other day 15 times into recipients fed control diet. Afterward, we used flow cytometry to analyze populations of CD3

Indexed as

Black raspberriesCD8+ T cellsFecal material transplantationFruits and vegetablesImmune systemNatural killer cells

Identifiers

PMID34308364
PMCPMC8301209
OpenAlexW3047285081

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.