ArticleEClinicalMedicine2021
MRI combined with early clinical variables are excellent outcome predictors for newborn infants undergoing therapeutic hypothermia after perinatal asphyxia.
Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- MRI scoring systems in neonatal encephalopathy and neurodevelopmental outcomes: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2026Pooled it
- Prevalence of hearing impairment in neonatal encephalopathy due to hypoxia-ischemia: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
- Predictors of outcome following neonatal encephalopathy in low- and middle-income countries: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Pooled it
- Magnetic resonance imaging and spectroscopy in neonatal encephalopathy: current consensus position and future opportunities.Pediatric research · 2026Review
- Neonatal encephalopathy and hypoxic-ischemic encephalopathy: the state of the art.Pediatric research · 2025Review
- Admissions and outcomes after perinatal asphyxia and hypoxic-ischaemic encephalopathy before and after therapeutic hypothermia: a retrospective population-based study.BMJ paediatrics open · 2025Article
- Placental histology for infants with hypoxic ischaemic encephalopathy compared with healthy controls: a case-control study.BMC pediatrics · 2025Article
- Ethical Dilemmas in Newborn Infants with Hypoxic Ischemic Encephalopathy.Asian bioethics review · 2025Article
- Development and Validation of an MRI-Based Brain Volumetry Model Predicting Poor Psychomotor Outcomes in Preterm Neonates.Journal of clinical medicine · 2025Article
- Measuring the time it takes to achieve full oral feeding can be used as a low-resource tool to assess neurologic recovery after perinatal asphyxia.Journal of tropical pediatrics · 2025Article
- Individualized Neuroprognostication in Neonates With Hypoxic-Ischemic Encephalopathy Treated With Hypothermia.Neurology. Clinical practice · 2025Article
- Slow rewarming after hypothermia does not ameliorate white matter injury after hypoxia-ischemia in near-term fetal sheep.Pediatric research · 2025Article
- Predictors of Death or Severe Impairment in Neonates With Hypoxic-Ischemic Encephalopathy.JAMA network open · 2024Article
- "Feed-and-wrap" technique versus deep sedation for neonatal magnetic resonance imaging: a retrospective comparative study.European radiology · 2024Article
- MRI predictors of long-term outcomes of neonatal hypoxic ischaemic encephalopathy: a primer for radiologists.The British journal of radiology · 2024Review
- Advancing brain MRI as a prognostic indicator in hypoxic-ischemic encephalopathy.Pediatric research · 2024Article
- The predictive role of brain magnetic resonance imaging in neonates with hypoxic-ischemic encephalopathy.Pediatric research · 2024Article
- Resting-state functional connectivity in children cooled for neonatal encephalopathy.Brain communications · 2024Article
- A bibliometric study on clinical research in neonatal encephalopathy.Frontiers in pediatrics · 2024Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBinary prediction-models for outcome [death, cognition, presence and severity of cerebral palsy (CP)], using MRI and early clinical data applicable for individual outcome prediction have not been developed.
methodsFrom Dec 1
findingsHIE and entry-aEEG severity were stable throughout the study. Outcome was favourable in 133/178 infants and adverse in 45/178: 17 died, 28 had low Cognition/Language scores, (including 9 with severe CP and 6 mild); seven had mild CP with favourable cognitive outcome. WMxBGT product scores and TIS were strong outcome predictors, and prediction improved when clinical/biochemical variables were added in binary logistic regression. The Positive Predictive Value for adverse outcome was 88%, increasing to 95% after excluding infants with PNC and additional diagnoses. Using WMxBGT in the regression predicted 8 of the 9 children with severe CP.
interpretationBinary logistic regression with WMxBGT or TIS and clinical variables gave excellent outcome prediction being 12% better than single variable cross-tabulation. Our MRI scoring and regression models are readily accessible and deserve investigation in other cohorts for group and individual prediction.
fundingWe thank the National Health Service (NHS) and our Universities and funders in UK and Norway: SPARKS, The Moulton Foundation, The Norwegian Research Council, The Lærdal Foundation for Acute Medicine and charitable donations for their support for cooling therapy.
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