Evidence map›Paper›PMID 34308156›Full record

ArticleThe East African health research journal2017

Gridlock from Diagnosis to Treatment of Multidrug-Resistant Tuberculosis (MDR-TB) in Tanzania: Illuminating Potential Factors for Possible Intervention.

Alphonce A Liyoyo, Scott K Heysell, Riziki M Kisonga, Johnson J Lyimo, Liberate J Mleoh, Beatrice K Mutayoba, Isaack A Lekule, Blandina T Mmbaga, Gibson S Kibiki, Stellah G Mpagama

Open access · diamondAbstract read
In one paragraph

Article in The East African health research journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Use of a molecular bacterial load assay to distinguish between active TB and post-TB lung disease.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Alphonce A LiyoyoKilimanjaro Christian Medical University College, Moshi, Tanzania.
Scott K HeysellDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Riziki M KisongaKibong'oto Infectious Disease Hospital, Kilimanjaro, Tanzania.
Johnson J LyimoNational TB and Leprosy Programme, Ministry of Health, Community Development, Gender, Elderly and Children, Dar es Salaam, Tanzania.
Liberate J MleohNational TB and Leprosy Programme, Ministry of Health, Community Development, Gender, Elderly and Children, Dar es Salaam, Tanzania.
Beatrice K MutayobaNational TB and Leprosy Programme, Ministry of Health, Community Development, Gender, Elderly and Children, Dar es Salaam, Tanzania.
Isaack A LekuleKibong'oto Infectious Disease Hospital, Kilimanjaro, Tanzania.
Blandina T MmbagaKilimanjaro Christian Medical University College, Moshi, Tanzania.
Gibson S KibikiKilimanjaro Christian Medical University College, Moshi, Tanzania.
Stellah G MpagamaKilimanjaro Christian Medical University College, Moshi, Tanzania.
Kilimanjaro Christian Medical Centre · TZMinistry of Health, Community Development, Gender, Elderly and Children · TZUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

settingsKibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania.

objectiveCharacterise multidrug-resistant tuberculosis (MDR-TB)-treated cases during the scaling up of molecular diagnostics using Xpert MTB/RIF and GenoType MTBDRplus.

designRetrospective cohort study.

resultsA total of 223 MDR-TB patients were referred to the Kibong'oto Infectious Disease Hospital from January 2013 through December 2014. Four cities-Dar es Salaam, Mbeya, Mwanza, and Tanga-contributed 144 (65%) of referrals. Of the total referred patients, HIV coinfection was found in 92 (41%) and 180 (81%) had history of previous TB treatment. Molecular drug susceptibility testing (DST) contributed 201 (91%) of referrals and resulted in a shorter time from diagnosis to start of treatment, 30 days (95% confidence interval [CI], 26-37), compared to conventional phenotypic DST, 212 days (95% CI, 151-272;

conclusionMolecular diagnostics appear to speedup the time to treatment initiation, but may not improve other treatment outcomes.

Identifiers

PMID34308156
PMCPMC8279266
OpenAlexW2752976591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.