Evidence map›Paper›PMID 34308155›Full record

ArticleThe East African health research journal2017

Tuberculosis Infection: Occurrence and Risk Factors in Presumptive Tuberculosis Patients of the Serengeti Ecosystem in Tanzania.

Erasto V Mbugi, Bugwesa Z Katale, Athumani M Lupindu, Julius D Keyyu, Sharon L Kendall, Hazel M Dockrell, Anita L Michel, Mecky I Matee, Paul D van Helden

Abstract read
In one paragraph

Article in The East African health research journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. 'One Health´ approach to end zoonotic TB.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Erasto V MbugiDepartment of Biochemistry, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Bugwesa Z KataleDepartments of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Athumani M LupinduDepartment of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania.
Julius D KeyyuTanzania Wildlife Research Institute, Arusha, Tanzania.
Sharon L KendallThe Royal Veterinary College, London, United Kingdom.
Hazel M DockrellDepartment of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Anita L MichelDepartment of Veterinary Tropical Diseases, University of Pretoria, Pretoria, South Africa.
Mecky I MateeDepartments of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Paul D van HeldenDST/NRF Centre of Excellence for Biomedical Tuberculosis Research/Medical Research Council, Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, South Africa.

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundCross-species tuberculosis (TB) transmission between humans and animals has been reported for quite a long time in sub-Saharan Africa. Because humans and animals coexist in the same ecosystem, exploring their potential for cross-species transmission and the impact the disease may have on the health of humans, animals, and their products is critical.

objectivesThis study aimed to identify risk factors for transmission of TB ( METHODOLOGY: We administered a semi-structured questionnaire to 421 self-reporting patients to gather information on risk factors and TB occurrence. In a parallel study, researchers screened sputum smears using Ziehl-Neelsen staining and confirmed by mycobacterial culture. We then performed descriptive statistics (Pearson's chi-square test) and logistic regression analysis to establish frequencies, association, and quantification of the risk factors associated with TB cases.

resultsOur findings showed 44% (95% confidence interval [CI], 0.40-0.49) of the results were positive from sputum samples collected over a 1-year duration in areas with a high TB burden, particularly the Bunda district, followed by the Serengeti and Ngorongoro districts. Of the culture-positive patients who also had infections other than TB (43/187 patients), 21 (49%) were HIV positive. Contact with livestock products (odds ratio [OR] 6.0; 95% CI, 1.81-19.9), infrequent milk consumption (OR 2.5; 95% CI, 1.42-4.23), cigarette smoking (OR 2.9; 95% CI, 1.19-7.1.2), and alcohol consumption (OR 2.3; 95% CI, 1.22-4.23) were associated with a higher likelihood of TB infection.

conclusionThere was no evidence of direct cross-species transmission of either

Identifiers

PMID34308155
PMCPMC8279301

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.