Evidence map›Paper›PMID 34307971›Full record

ArticleKidney international reports2021

Acute Kidney Injury Incidence, Recovery, and Long-term Kidney Outcomes Among Hospitalized Patients With COVID-19 and Influenza.

Ian A Strohbehn, Sophia Zhao, Harish Seethapathy, Meghan Lee, Nifasha Rusibamayila, Andrew S Allegretti, Xavier Vela Parada, Meghan E Sise

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ian A StrohbehnDepartment of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Sophia ZhaoDepartment of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Harish SeethapathyDepartment of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Meghan LeeDepartment of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Nifasha RusibamayilaDepartment of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Andrew S AllegrettiDepartment of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Xavier Vela ParadaDepartment of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Meghan E SiseDepartment of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Massachusetts General Hospital · US

Funding

Effect of Covid-19 on chronic kidney disease progressionR03DK128533 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SISE, MEGHAN E. · 2021 to 2022
$252k
NIDDK NIH HHS R03 DK128533
6 · The paper itself

Abstract

introductionAcute kidney injury (AKI) is a common complication in patients with severe COVID-19. We sought to compare the AKI incidence and outcomes among patients hospitalized with COVID-19 and with influenza.

methodsThis was a retrospective cohort study of patients with COVID-19 hospitalized between March and May 2020 and historical controls hospitalized with influenza A or B between January 2017 and December 2019 within a large health care system. Cox proportional hazards models were used to compare the risk of AKI during hospitalization. Secondary outcomes included AKI recovery, mortality, new-onset chronic kidney disease (CKD), and ≥25% estimated glomerular filtration rate (eGFR) decline.

resultsA total of 2425 patients were included; 1091 (45%) had COVID-19, and 1334 (55%) had influenza. The overall AKI rate was 23% and 13% in patients with COVID-19 and influenza, respectively. Compared with influenza, hospitalized patients with COVID-19 had an increased risk of developing AKI (adjusted hazard ratio [aHR] = 1.58; 95% confidence interval [CI], 1.29-1.94). Patients with AKI were more likely to die in the hospital when infected with COVID-19 versus influenza (aHR = 3.55; 95% CI, 2.11-5.97). Among patients surviving to hospital discharge, the rate of AKI recovery was lower in patients with COVID-19 (aHR = 0.47; 95% CI, 0.36-0.62); however, among patients followed for ≥90 days, new-onset CKD (aHR = 1.24; 95% CI, 0.86-1.78) and ≥25% eGFR decline at the last follow-up (aHR = 1.36, 95% CI, 0.97-1.90) were not significantly different between the cohorts.

conclusionAKI and mortality rates are significantly higher in patients with COVID-19 than influenza; however, kidney recovery among long-term survivors appears to be similar.

Indexed as

acute kidney injuryCOVID-19influenzamortality

Identifiers

PMID34307971
PMCPMC8280679
OpenAlexW3185217136

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.