Evidence map›Paper›PMID 34307937›Full record

ArticleHeliyon2021

Ameliorating effect of melatonin on mercuric chloride-induced neurotoxicity in rats.

Eman S Said, Radwa M Ahmed, Rehab A Mohammed, Enas M Morsi, Mohamed H Elmahdi, Hassan S Elsayed, Rania H Mahmoud, Eman H Nadwa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Journal of experimental pharmacology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Eman S SaidDepartment of Clinical Pharmacology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Radwa M AhmedDepartment of Anatomy and Embryology, Faculty of Medicine, Fayoum University, Egypt.
Rehab A MohammedDepartment of Medical Physiology, Faculty of Medicine, Fayoum University, Egypt.
Enas M MorsiDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Fayoum University, Egypt.
Mohamed H ElmahdiDepartment of Pathology, Faculty of Medicine, Fayoum University, Egypt.
Hassan S ElsayedDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Egypt.
Rania H MahmoudDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Egypt.
Eman H NadwaDepartment of Pharmacology and Therapeutics, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
Fayoum University · EGCairo University · EGQassim University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mercury is a highly toxic metal. It induces its toxicity via production of reactive oxygen species. Brain tissues are more susceptible to oxidative damage. Melatonin and its metabolites are free radical scavengers. The aim of this work is to elucidate the neuroprotective effect of melatonin on mercuric chloride-induced neurotoxicity in rats. Fifty male albino rats were used and divided into five groups. Group I acts as normal control. Group II (LD HgCl

Indexed as

Cerebral cortexMelatoninMercuric chlorideNeurotoxicityOxidative stress

Identifiers

PMID34307937
PMCPMC8287146
OpenAlexW3182484682

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.