Evidence map›Paper›PMID 34307918›Full record

ArticlePhysics and imaging in radiation oncology2021

Risk of radiation-induced second malignant neoplasms from photon and proton radiotherapy in paediatric abdominal neuroblastoma.

Sophie Taylor, Pei Lim, Reem Ahmad, Ammar Alhadi, William Harris, Vasilis Rompokos, Derek D'Souza, Mark Gaze, Jennifer Gains, Catarina Veiga

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physics and imaging in radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sophie TaylorCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Pei LimDepartment of Oncology, University College London Hospitals NHS Foundation Trust, London, UK.
Reem AhmadCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Ammar AlhadiCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
William HarrisCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Vasilis RompokosRadiotherapy Physics Services, University College London Hospitals NHS Foundation Trust, London, UK.
Derek D'SouzaRadiotherapy Physics Services, University College London Hospitals NHS Foundation Trust, London, UK.
Mark GazeDepartment of Oncology, University College London Hospitals NHS Foundation Trust, London, UK.
Jennifer GainsDepartment of Oncology, University College London Hospitals NHS Foundation Trust, London, UK.
Catarina VeigaCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
University College London · GBUniversity College London Hospitals NHS Foundation Trust · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

background and purposeState-of-the-art radiotherapy modalities have the potential of reducing late effects of treatment in childhood cancer survivors. Our aim was to investigate the carcinogenic risk associated with 3D conformal (photon) radiation (3D-CRT), intensity modulated arc therapy (IMAT) and pencil beam scanning proton therapy (PBS-PT) in the treatment of paediatric abdominal neuroblastoma. MATERIALS AND

methodsThe risk of radiation-induced second malignant neoplasm (SMN) was estimated using the concept of organ equivalent dose (OED) for eleven organs (lungs, rectum, colon, stomach, small intestine, liver, bladder, skin, central nervous system (CNS), bone, and soft tissues). The risk ratio (RR) between radiotherapy modalities and lifetime absolute risks (LAR) were reported for twenty abdominal neuroblastoma patients (median, 4y; range, 1-9y) historically treated with 3D-CRT that were also retrospectively replanned for IMAT and PBS-PT.

resultsThe risk of SMN due to primary radiation was reduced in PBS-PT against 3D-CRT and IMAT for most patients and organs. The RR across all organs ranged from 0.38 ± 0.22 (bladder) to 0.98 ± 0.04 (CNS) between PBS-PT and IMAT, and 0.12 ± 0.06 (rectum and bladder) to 1.06 ± 0.43 (bone) between PBS-PT and 3D-CRT. The LAR for most organs was within 0.01-1% (except the colon) with a cumulative risk of 21 ± 13%, 35 ± 14% and 35 ± 16% for PBS-PT, IMAT and 3D-CRT, respectively.

conclusionsPBS-PT was associated with the lowest risk of radiation-induced SMN compared to IMAT and 3D-CRT in abdominal neuroblastoma treatment. Other clinical endpoints and plan robustness should also be considered for optimal plan selection.

Indexed as

Abdominal neuroblastomaChildhood cancerIntensity modulated arc therapy (IMAT)PaediatricPencil beam scanningProton therapySecond malignant neoplasm

Identifiers

PMID34307918
PMCPMC8295851
OpenAlexW3179315561

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.