Evidence map›Paper›PMID 34307899›Full record

ArticleJournal of psychiatry and brain science2021

Computerized Assessment of Psychosis Risk.

Vijay A Mittal, Lauren M Ellman, Gregory P Strauss, Elaine F Walker, Philip R Corlett, Jason Schiffman, Scott W Woods, Albert R Powers, Steven M Silverstein, James A Waltz and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of psychiatry and brain science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Environmental Exposures and Computational Mechanisms in Psychosis Risk: Insights from a Multi-Site Cohort.Clinical psychological science : a journal of the Association for Psychological Science · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 1 country.

Vijay A MittalInstitutes for Policy Research (IPR) and Innovations in Developmental Sciences (DevSci), Departments of Psychology, Psychiatry, Medical Social Sciences, Northwestern University, Evanston, IL 60208, USA.
Lauren M EllmanDepartment of Psychology, Temple University, Philadelphia, PA 19122, USA.
Gregory P StraussDepartments of Psychology and Neuroscience, University of Georgia, Athens, GA 30602, USA.
Elaine F WalkerDepartment of Psychology and Program in Neuroscience, Emory University, Atlanta, GA 30322, USA.
Philip R CorlettDepartment of Psychiatry, Yale University, New Haven, CT 06519, USA.
Jason SchiffmanDepartment of Psychological Science, 4201 Social and Behavioral Sciences Gateway, University of California, Irvine, CA 92697, USA.
Scott W WoodsDepartment of Psychiatry, Yale University, New Haven, CT 06519, USA.
Albert R PowersDepartment of Psychiatry, Yale University, New Haven, CT 06519, USA.
Steven M SilversteinCenter for Visual Science, Departments of Psychiatry, Neuroscience and Ophthalmology, University of Rochester Medical Center, Rochester, NY 14642, USA.
James A WaltzMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA.
Richard ZinbargDepartment of Psychology, Northwestern University, Evanston, IL 60208, USA.
Shuo ChenMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA.
Trevor WilliamsDepartment of Psychology, Northwestern University, Evanston, IL 60208, USA.
Joshua KenneyDepartment of Psychiatry, Yale University, New Haven, CT 06519, USA.
James M GoldMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA.
Yale University · USUniversity of Maryland, Baltimore · USNorthwestern University · USEmory University · USFamily Research Institute · USTemple University · USUniversity of California, Irvine · USUniversity of Georgia · USUniversity of Rochester Medical Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
2/9 - Predictors and Mechanisms of Conversion to PsychosisU01MH081988 · NIMH · EMORY UNIVERSITY · PI WALKER, ELAINE FRAN · 2008 to 2018
$5.4M
5/5 CAPER: Computerized Assessment of Psychosis RiskR01MH120089 · NIMH · YALE UNIVERSITY · PI CORLETT, PHILIP, WOODS, SCOTT W · 2020 to 2024
$3.1M
Prodromal Inventory for Negative Symptoms (PINS): A Development and Validation StudyR01MH116039 · NIMH · UNIVERSITY OF GEORGIA · PI MITTAL, VIJAY A, STRAUSS, GREGORY P · 2019 to 2023
$3.1M
1/5 CAPER: Computerized Assessment of ProdromE RiskR01MH120090 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI GOLD, JAMES M. · 2020 to 2024
$2.9M
4/5 CAPER: Computerized assessment of psychosis riskR01MH120092 · NIMH · UNIVERSITY OF GEORGIA · PI STRAUSS, GREGORY P · 2020 to 2024
$2.0M
2/5 CAPER Computerized assessment of psychosis riskR01MH120088 · NIMH · NORTHWESTERN UNIVERSITY · PI MITTAL, VIJAY A · 2020 to 2024
$2.0M
1/3-Community Psychosis Risk Screening: An Instrument Development Study SupplementR01MH112613 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ELLMAN, LAUREN M · 2017 to 2022
$1.8M
CAPER: Computerized Assessment of Psychosis Risk SupplementR01MH120091 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ELLMAN, LAUREN M · 2020 to 2024
$1.6M
Administrative Supplement - 3/3: Community Psychology Risk Screening: An Instrument Development StudyR01MH112612 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI PITTS, STEVEN C, SCHIFFMAN, JASON E · 2017 to 2022
$1.3M
2/3 Community psychosis risk screening: An instrument development studyR01MH112545 · NIMH · NORTHWESTERN UNIVERSITY · PI MITTAL, VIJAY A · 2017 to 2021
$1.2M
A Hearing Test for Hallucinations: Toward Development of Computational Markers for Early DiagnosisK23MH115252 · NIMH · YALE UNIVERSITY · PI POWERS, ALBERT R · 2018 to 2022
$983k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K23 MH115252NIMH NIH HHS R01 MH112545NIMH NIH HHS R01 MH112612NIMH NIH HHS R01 MH112613NIMH NIH HHS R01 MH116039NIMH NIH HHS R01 MH120088NIMH NIH HHS R01 MH120089NIMH NIH HHS R01 MH120090NIMH NIH HHS R01 MH120091NIMH NIH HHS R01 MH120092NIMH NIH HHS R21 MH119438NIMH NIH HHS U01 MH081988
6 · The paper itself

Abstract

Early detection and intervention with young people at clinical high risk (CHR) for psychosis is critical for prevention efforts focused on altering the trajectory of psychosis. Early CHR research largely focused on validating clinical interviews for detecting at-risk individuals; however, this approach has limitations related to: (1) specificity (i.e., only 20% of CHR individuals convert to psychosis) and (2) the expertise and training needed to administer these interviews is limited. The purpose of our study is to develop the computerized assessment of psychosis risk (CAPR) battery, consisting of behavioral tasks that require minimal training to administer, can be administered online, and are tied to the neurobiological systems and computational mechanisms implicated in psychosis. The aims of our study are as follows: (1A) to develop a psychosis-risk calculator through the application of machine learning (ML) methods to the measures from the CAPR battery, (1B) evaluate group differences on the risk calculator score and test the hypothesis that the risk calculator score of the CHR group will differ from help-seeking and healthy controls, (1C) evaluate how baseline CAPR battery performance relates to symptomatic outcome two years later (i.e., conversion and symptomatic worsening). These aims will be explored in 500 CHR participants, 500 help-seeking individuals, and 500 healthy controls across the study sites. This project will provide a next-generation CHR battery, tied to illness mechanisms and powered by cutting-edge computational methods that can be used to facilitate the earliest possible detection of psychosis risk.

Indexed as

behavioral tasksclinical high-riskcomputational psychiatrycomputerized assessmentprecision medicineprodromepsychosisrisk calculatorrisk screeningschizophrenia

Identifiers

PMID34307899
PMCPMC8302046
OpenAlexW3174583390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.