Evidence map›Paper›PMID 34307898›Full record

ArticleJournal of psychiatry and brain science2021

Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies.

Xianjin Zhou

Open access · diamondAbstract read
In one paragraph

Article in Journal of psychiatry and brain science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Pro-Cognitive Effects of IgM Isotype Anti-NMDAR1 Autoantibodies in Mice.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Xianjin ZhouDepartment of Psychiatry, University of California San Diego, La Jolla, 92093, California, USA.
University of California, San Diego · US

Funding

Modeling Anti-NMDAR1 Autoantibodies in Psychiatric DisordersR21MH123705 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHOU, XIANJIN · 2020 to 2020
$434k
Neuroinflammation in Generation of NMDAR AutoantibodiesR21MH116186 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHOU, XIANJIN · 2019 to 2020
$433k
NIMH NIH HHS R21 MH116186NIMH NIH HHS R21 MH123705
6 · The paper itself

Abstract

Antibodies persist months and years in blood. Chronic presence of low titers of blood circulating anti-NMDAR1 autoantibodies are sufficient to impair cognitive function in the integrity of the BBB in mice, suggesting potential cognitive damaging effects of low titers of blood circulating anti-NMDAR1 autoantibodies in the general human population and psychiatric patients. Investigation of anti-NMDAR1 autoantibodies against individual NMDAR1 antigenic epitopes may potentially provide risk biomarkers and therapeutic targets for development of immunotherapy as a precision medicine for psychiatric patients in the future.

Indexed as

antigenic epitopeanti-NMDAR1 autoantibodiescognitive impairment

Identifiers

PMID34307898
PMCPMC8301263
OpenAlexW3174512796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.