Evidence map›Paper›PMID 34307685›Full record

ArticleBioMed research international2021

Hydroxyphenyl Butanone Induces Cell Cycle Arrest through Inhibition of GSK3

Songyan Zhang, Yunfeng Wang, Haopeng Zhang, Chengming Sun, Shuwei Dang, Ming Liu

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Songyan ZhangDepartment of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Yunfeng WangDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Haopeng ZhangDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Chengming SunDepartment of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Shuwei DangDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Ming LiuDepartment of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.ORCID https://orcid.org/0000-0003-4548-2683
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is among the top three gastrointestinal malignancy in morbidity and mortality. The abnormal activation of Wnt/

methodsCell proliferation was detected after hydroxyphenyl butanone treatment in human colorectal cancer HCT116, LOVO, and normal colonic epithelial NCM460 cells. Colony formation, cell invasion ability, and cell cycle were detected with and without GSK-3

resultsHydroxyphenyl butanone induces cycle arresting on G1-S phase of colorectal cancer cell line through GSK3

conclusionThis study illustrated natural hydroxyphenyl butanone as new inhibitor of GSK3

Indexed as

ButanonesCell Cycle CheckpointsCell Line, TumorCell ProliferationColorectal NeoplasmsG1 PhaseGlycogen Synthase Kinase 3 betaHumansNeoplasm InvasivenessPlant ExtractsRubusS PhaseTumor Stem Cell AssayWnt Signaling PathwayButanonesGlycogen Synthase Kinase 3 betaPlant Extracts

Identifiers

PMID34307685
PMCPMC8272657
OpenAlexW3182181885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.