ArticleWorld journal of clinical cases2021
Herb-induced liver injury: Systematic review and meta-analysis.
Article in World journal of clinical cases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 78 citations in OpenAlex.
- Herbal, dietary supplements, oligo and trace elements consumption among chronic liver disease patients and caregivers: a cross-sectional study.Internal and emergency medicine · 2026Article
- Autoimmune Hepatitis Induced by Immune Checkpoint Inhibitors in Adults: A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Review
- Beyond the Tipping Point: Advances in the Diagnosis and Management of Acute-on-Chronic Liver Failure and End-Stage Liver Disease.Diagnostics (Basel, Switzerland) · 2026Review
- Herb-Induced Liver Injury byLife (Basel, Switzerland) · 2026Article
- Hematological and clinical-chemistry parameters of kratom users: a comparative study of users and non-users in Southern Thailand.Scientific reports · 2026Article
- An Unforeseen Diagnosis After Liver Transplantation for Acute Liver Failure: Extranodal NK/T-Cell Lymphoma.Case reports in hepatology · 2026Article
- Short-term Liver Safety ofActa medica Philippina · 2026Article
- Patterns of complementary and alternative medicine use in pediatric patients with inflammatory bowel disease.Journal of pediatric gastroenterology and nutrition · 2026Article
- Nonclinical Safety Evaluation of Nonmutagenic Immunogrit Following Subacute 28-Day Repeated Dose Oral Toxicity in Sprague-Dawley Rats With GLP Compliance.Journal of toxicology · 2026Article
- Delayed-Onset Hepatocellular Liver Injury Associated With Nitrofurantoin and Herbal Supplement Use: A Case Report With Multiple Potential Exposures.Case reports in gastrointestinal medicine · 2026Article
- Cefadroxil-associated cholestatic liver injury presenting as vanishing bile duct syndrome: a case report.Frontiers in medicine · 2026Article
- Green Tea Catechins Mitigate Hepatocyte Ferroptosis Through Attenuation of Oxidative Stress and Improvement of Antioxidant Systems.Antioxidants (Basel, Switzerland) · 2025Article
- Use of dietary supplements by individuals with dementia - the caregivers' perspective.Scandinavian journal of primary health care · 2025Article
- Probable Cinnamon-Induced Mixed Hepatocellular-Cholestatic Liver Injury in a Young Woman: A Case Report.Cureus · 2025Article
- Herbal Weight Loss Supplements Induce Metabolomic In Vitro Changes Indicative of Oxidative Stress.Metabolites · 2025Article
- Acute and sub-acute toxicity assessment of methanolic stem bark extract of Khaya anthotheca (Meliaceae) in Wistar rats.Tropical medicine and health · 2025Article
- Phytochemical Compounds as Promising Therapeutics for Intestinal Fibrosis in Inflammatory Bowel Disease: A Critical Review.Nutrients · 2024Review
- Herbal and Non-Herbal Dietary Supplements for Psychiatric Indications: Considerations in Liver Transplantation.Current psychiatry reports · 2024Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of herbal supplements and alternative medicines has been increasing in the last decades. Despite popular belief that the consumption of natural products is harmless, herbs might cause injury to various organs, particularly to the liver, which is responsible for their metabolism in the form of herb-induced liver injury (HILI).
aimTo identify herbal products associated with HILI and describe the type of lesion associated with each product.
methodsStudies were retrieved using Medical Subject Headings Descriptors combined with Boolean operators. Searches were run on the electronic databases Scopus, Web of Science, MEDLINE, BIREME, LILACS, Cochrane Library for Systematic Reviews, SciELO, Embase, and Opengray.eu. Languages were restricted to English, Spanish, and Portuguese. There was no date of publication restrictions. The reference lists of the studies retrieved were searched manually. To access causality, the Maria and Victorino System of Causality Assessment in Drug Induced Liver Injury was used. Simple descriptive analysis were used to summarize the results.
resultsThe search strategy retrieved 5918 references. In the final analysis, 446 references were included, with a total of 936 cases reported. We found 79 types of herbs or herbal compounds related to HILI. He-Shou-Wu, Green tea extract, Herbalife, kava kava, Greater celandine, multiple herbs, germander, hydroxycut, skullcap, kratom, Gynura segetum, garcinia cambogia, ma huang, chaparral, senna, and aloe vera were the most common supplements with HILI reported. Most of these patients had complete clinical recovery (82.8%). However, liver transplantation was necessary for 6.6% of these cases. Also, chronic liver disease and death were observed in 1.5% and 10.4% of the cases, respectively.
conclusionHILI is normally associated with a good prognosis, once the implied product is withdrawn. Nevertheless, it is paramount to raise awareness in the medical and non-medical community of the risks of the indiscriminate use of herbal products.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.