ArticleFrontiers in veterinary science2021
Feeding Pre-weaned Calves With Waste Milk Containing Antibiotic Residues Is Related to a Higher Incidence of Diarrhea and Alterations in the Fecal Microbiota.
Article in Frontiers in veterinary science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Impact of ceftiofur administration andmSystems · 2026Article
- Epidemiology of Antimicrobial Residues and Phenotypic Resistance of Bacterial Isolates from Waste Milk on California Dairies.Microorganisms · 2026Article
- Unraveling the dynamic changes in the intestinal microbiome: impacts on pre-weaning calf health and productivity.Journal of animal science and biotechnology · 2026Review
- Progress in the application of traditional Chinese medicine and natural products for the prevention and treatment of calf diarrhea: a review.Frontiers in veterinary science · 2026Review
- Evaluation of ß-lactamase-induced inactivation of penicillin G and cefoperazone in spiked ultra-high temperature and raw unpasteurized milk.Frontiers in veterinary science · 2026Article
- Exploring colostrum microbiota and its influence on early calf gut microbiota development using full-length 16S rRNA gene metabarcoding.Scientific reports · 2025Article
- Multiblock Analysis of Risk Factors and Management Areas of Calf Mortality in Large-Scale Dairy Herds.Animals : an open access journal from MDPI · 2025Article
- Assessing the Impacts of Dairy Farm Antimicrobial Use on the Bovine Fecal Microbiome.Animals : an open access journal from MDPI · 2025Article
- A Framework for Comprehensive Dairy Calf Health Investigations.Animals : an open access journal from MDPI · 2025Review
- Progression of the faecal microbiome in preweaning dairy calves that develop cryptosporidiosis.Animal microbiome · 2025Article
- Analysis of pathogenic bacteria and antimicrobial residues in bovine waste milk on dairy farms in southern Chile.Frontiers in veterinary science · 2025Article
- Efficacy of Copper Ion Treatment on Bacteria and Antibiotic Residues Contained in Bovine Waste Milk.Antibiotics (Basel, Switzerland) · 2024Article
- Dynamic Analysis of Stool Microbiota of Simmental Calves and Effects of Diarrhea on Their Gut Microbiota.Biology · 2024Article
- Farmers' Biosecurity Awareness in Small-Scale Alpine Dairy Farms and the Crucial Role of Veterinarians.Animals : an open access journal from MDPI · 2024Article
- When the solution becomes the problem: a review on antimicrobial resistance in dairy cattle.Future microbiology · 2024Review
- Heat Inactivation of Methicillin-ResistantAnimals : an open access journal from MDPI · 2023Article
- Revisiting the Intestinal Microbiome and Its Role in Diarrhea and Constipation.Microorganisms · 2023Review
- Effect of the Selective Dry Cow Therapy on Udder Health and Milk Microbiota.Antibiotics (Basel, Switzerland) · 2023Article
- Fecal microbiota dynamics and its relationship to diarrhea and health in dairy calves.Journal of animal science and biotechnology · 2022Article
- Invited Review: Antimicrobial Use and Antimicrobial Resistance in Pathogens Associated with Diarrhea and Pneumonia in Dairy Calves.Animals : an open access journal from MDPI · 2022Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cows receiving antibiotics for intra-mammary infection (IMI) produce milk that cannot be marketed. This is considered waste milk (WM), and a convenient option for farmers is using it as calf food. However, adding to the risk of selecting resistant bacteria, residual antibiotics might interfere with the gut microbiome development and influence gastrointestinal health. We assessed the longitudinal effect of unpasteurized WM containing residual cefalexin on calf intestinal health and fecal microbiota in an 8-week trial. After 3 days of colostrum, six calves received WM and six calves received bulk tank milk (BM) for 2 weeks. For the following 6 weeks, all 12 calves received milk substitute and starter feed. Every week for the first 2 weeks and every 2 weeks for the remaining 6 weeks, we subjected all calves to clinical examination and collected rectal swabs for investigating the fecal microbiota composition. Most WM calves had diarrhea episodes in the first 2 weeks of the trial (5/6 WM and 1/6 BM), and their body weight was significantly lower than that of BM calves. Based on 16S rRNA gene analysis, WM calves had a lower fecal microbiota alpha diversity than that in BM calves, with the lowest
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