ReviewFrontiers in medicine2021
Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes.
Review in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Incidence of infectious endophthalmitis after keratoplasty surgery: an updated systematic review and meta-analysis.Infection · 2026Pooled it
- Toward clinically relevant automated corneal biomanufacturing with human-derived FBS alternatives.Scientific reports · 2026Article
- Biofilm-related characteristics ofFrontiers in cellular and infection microbiology · 2026Article
- Contact lens-related versus non-contact lens-relatedFrontiers in medicine · 2026Article
- Vision rehabilitation of post-Descemet membrane endothelial keratoplasty Pseudomonas keratitis utilizing losartan ophthalmic solution and scleral contact lens: a case report.Journal of medical case reports · 2025Article
- Comparative Evaluation of Temperature, Bottle Type, and Amphotericin B on Fungal Detection in Corneal Preservation Media Using the BACT/ALERT SystemMicroorganisms · 2025Article
- 3D Differentiation of Bone-Marrow Derived Mesenchymal Stromal Cells into the Keratocyte Lineage for Corneal Bioprinting.Advanced healthcare materials · 2025Article
- Clinical application of anterior segment optical coherence tomography in ocular emergencies: A comprehensive review.The Journal of international medical research · 2025Review
- Cyclosporine eye drops in lattice corneal dystrophy type 1: case report.Annals of medicine and surgery (2012) · 2025Article
- Outcomes of Post-Keratoplasty Microbial Keratitis: A 16-Year Analysis.Journal of clinical medicine · 2025Article
- Clinical characteristics and risk factors for readmission after deep anterior lamellar keratoplasty: a nationwide, cross-sectional, multicenter study.BMC ophthalmology · 2025Article
- Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes.Journal of fungi (Basel, Switzerland) · 2024Article
- The Systemic Risk Factors for the Development of Infectious Keratitis after Penetrating Keratoplasty: A Population-Based Cohort Study.Diagnostics (Basel, Switzerland) · 2024Article
- Microbiological screening of corneas stored in organ culture medium at Lions Eye Bank of Western Australia from 2011 to 2022.International ophthalmology · 2024Article
- Unveiling the landscape of post-keratoplasty keratitis: a comprehensive epidemiological analysis in a tertiary center.International ophthalmology · 2024Article
- Post-Keratoplasty Microbial Keratitis in the Era of Lamellar Transplants-A Comprehensive Review.Journal of clinical medicine · 2024Review
- Clinical Applications of Anterior Segment Optical Coherence Tomography: An Updated Review.Diagnostics (Basel, Switzerland) · 2024Review
- Infectious keratitis in Western New York: a 10-year review of patient demographics, clinical management, and treatment failure.Frontiers in ophthalmology · 2024Article
- Clinical and in vivo confocal microscopy characteristics of Candida keratitis following keratoplasty.BMC ophthalmology · 2023Article
- A novel technique of penetrating keratoplasty to prevent intraocular contents extrusion for infectious keratitis.BMC ophthalmology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
Abstract
Post-keratoplasty infectious keratitis (PKIK) represents a unique clinical entity that often poses significant diagnostic and therapeutic challenges. It carries a high risk of serious complications such as graft rejection and failure, and less commonly endophthalmitis. Topical corticosteroids are often required to reduce the risk of graft rejection but their use in PKIK may act as a double-edged sword, particularly in fungal infection. The increased uptake in lamellar keratoplasty in the recent years has also led to complications such as graft-host interface infectious keratitis (IIK), which is particularly difficult to manage. The reported incidence of PKIK differs considerably across different countries, with a higher incidence observed in developing countries (9.2-11.9%) than developed countries (0.02-7.9%). Common risk factors for PKIK include the use of topical corticosteroids, suture-related problems, ocular surface diseases and previous corneal infection. PKIK after penetrating keratoplasty or (deep) anterior lamellar keratoplasty is most commonly caused by ocular surface commensals, particularly Gramme-positive bacteria, whereas PKIK after endothelial keratoplasty is usually caused by
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.