ReviewFrontiers in cell and developmental biology2021
Hippo-Yap Pathway Orchestrates Neural Crest Ontogenesis.
Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 17 citations in OpenAlex.
- Craniofacial development: genetics, signaling pathways, teratogenic mechanisms, and clinal significance.Molecular biomedicine · 2026Review
- Article
- Review
- ERK-Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- Article
- Acute exposure to electronic cigarette components alters mRNA expression of pre-osteoblasts.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Competence for neural crest induction is controlled by hydrostatic pressure through Yap.Nature cell biology · 2024Article
- Generation of Functional and Mature Sympathetic Neurons from Human Pluripotent Stem Cells via a Neuroepithelial Route.Journal of molecular neuroscience : MN · 2024Article
- Embryo movement is required for limb tendon maturation.Frontiers in cell and developmental biology · 2024Article
- Craniofacial Development Is Fine-Tuned by Sox2.Genes · 2023Review
- FGF signaling in cranial suture development and related diseases.Frontiers in cell and developmental biology · 2023Review
- Cardiac Neural Crest and Cardiac Regeneration.Cells · 2022Review
- Review
- Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo.Science signaling · 2022Article
- Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation.eLife · 2022Article
- Gene regulatory network from cranial neural crest cells to osteoblast differentiation and calvarial bone development.Cellular and molecular life sciences : CMLS · 2022Review
- Characterization of circular RNAs in dorsal root ganglia after central and peripheral axon injuries.Frontiers in cellular neuroscience · 2022Article
- Editorial: Metabolic Regulation in the Development of Cardiovascular Diseases.Frontiers in cell and developmental biology · 2021Article
- Reprogramming of trunk neural crest to a cranial crest-like identity alters their transcriptome and developmental potential.Differentiation; research in biological diversityArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Neural crest (NC) cells are a migratory stem cell population in vertebrate embryogenesis that can give rise to multiple cell types, including osteoblasts, chondrocytes, smooth muscle cells, neurons, glia, and melanocytes, greatly contributing to the development of different tissues and organs. Defects in NC development are implicated in many human diseases, such as numerous syndromes, craniofacial aberration and congenital heart defects. Research on NC development has gained intense interest and made significant progress. Recent studies showed that the Hippo-Yap pathway, a conserved fundamental pathway with key roles in regulation of cell proliferation, survival, and differentiation, is indispensable for normal NC development. However, the roles and mechanisms of the Hippo-Yap pathway in NC development remain largely unknown. In this review, we summarize the key functions of the Hippo-Yap pathway indicated in NC induction, migration, proliferation, survival, and differentiation, as well as the diseases caused by its dysfunction in NC cells. We also discuss emerging current and future studies in the investigation of the Hippo-Yap pathway in NC development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.