Evidence map›Paper›PMID 34307385›Full record

ReviewFrontiers in cell and developmental biology2021

Regulation of Alloantibody Responses.

Anita S Chong, Peter T Sage, Maria-Luisa Alegre

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. CD4Frontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Anita S ChongSection of Transplantation, Department of Surgery, University of Chicago, Chicago, IL, United States.
Peter T SageRenal Division, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Maria-Luisa AlegreSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, United States.
University of Chicago · USBrigham and Women's Hospital · US

Funding

Transgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BLAZAR, BRUCE R · 2003 to 2023
$42.5M
T cell mechanisms that distinguish robust tolerance from metastable allograft acceptance and failed tolerance (Project 2)P01AI097113 · NIAID · UNIVERSITY OF CHICAGO · PI Maria-Luisa Alegre, Anita S Chong · 2012 to 2026
$23.8M
Intrarenal B cells in acute kidney allograft rejectionR01AI148705 · NIAID · UNIVERSITY OF CHICAGO · PI CHONG, ANITA S, CLARK, MARCUS RAMSAY · 2020 to 2024
$4.0M
Humoral Immunoregulation of Allergic Disease by Follicular T Cell SubsetsR01AI153124 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter The Sage · 2021 to 2026
$3.2M
Deconstructing B cell transplantation toleranceR01AI142747 · NIAID · UNIVERSITY OF CHICAGO · PI CHONG, ANITA S · 2019 to 2022
$2.2M
NIAID NIH HHS P01 AI056299NIAID NIH HHS P01 AI097113NIAID NIH HHS R01 AI142747NIAID NIH HHS R01 AI148705NIAID NIH HHS R01 AI153124
6 · The paper itself

Abstract

The control of alloimmunity is essential to the success of organ transplantation. Upon alloantigen encounter, naïve alloreactive T cells not only differentiate into effector cells that can reject the graft, but also into T follicular helper (Tfh) cells that promote the differentiation of alloreactive B cells that produce donor-specific antibodies (DSA). B cells can exacerbate the rejection process through antibody effector functions and/or B cell antigen-presenting functions. These responses can be limited by immune suppressive mechanisms mediated by T regulatory (Treg) cells, T follicular regulatory (Tfr) cells, B regulatory (Breg) cells and a newly described tolerance-induced B (TIB) cell population that has the ability to suppress

Indexed as

alloantibodiesBregsTfhTfrtolerant B cellstransplantationtransplant tolerance

Identifiers

PMID34307385
PMCPMC8297544
OpenAlexW3178310384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.