Evidence map›Paper›PMID 34307378›Full record

ReviewFrontiers in cell and developmental biology2021

Stress Hormones: Emerging Targets in Gynecological Cancers.

Guoqiang Chen, Lei Qiu, Jinghai Gao, Jing Wang, Jianhong Dang, Lingling Li, Zhijun Jin, Xiaojun Liu

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Guoqiang ChenDepartment of Obstetrics and Gynecology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Lei QiuSchool of Pharmacy, Naval Medical University, Shanghai, China.
Jinghai GaoDepartment of Obstetrics and Gynecology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jing WangDepartment of Obstetrics and Gynecology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jianhong DangDepartment of Obstetrics and Gynecology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Lingling LiDepartment of Obstetrics and Gynecology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Zhijun JinDepartment of Obstetrics and Gynecology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Xiaojun LiuDepartment of Obstetrics and Gynecology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Shanghai Changzheng Hospital · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the past decade, several discoveries have documented the existence of innervation in ovarian cancer and cervical cancer. Notably, various neurotransmitters released by the activation of the sympathetic nervous system can promote the proliferation and metastasis of tumor cells and regulate immune cells in the tumor microenvironment. Therefore, a better understanding of the mechanisms involving neurotransmitters in the occurrence and development of gynecological cancers will be beneficial for exploring the feasibility of using inexpensive β-blockers and dopamine agonists in the clinical treatment of gynecological cancers. Additionally, this article provides some new insights into targeting tumor innervation and neurotransmitters in the tumor microenvironment.

Indexed as

dopamineepinephrineglucocorticoidsneurotrophic factorsnoradrenalineperineural invasiontumor immune microenvironment

Identifiers

PMID34307378
PMCPMC8299464
OpenAlexW3197357004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.