Evidence map›Paper›PMID 34307364›Full record

ReviewFrontiers in cell and developmental biology2021

ER-Phagy: A New Regulator of ER Homeostasis.

Ming Yang, Shilu Luo, Xi Wang, Chenrui Li, Jinfei Yang, Xuejing Zhu, Li Xiao, Lin Sun

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 76 citations in OpenAlex.

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  13. Early Transition Metal-Based Antitumor Complexes.Chemistry, an Asian journal · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ming YangDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, China.
Shilu LuoDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, China.
Xi WangDepartment of Nutrition, Xiangya Hospital, Central South University, Changsha, China.
Chenrui LiDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, China.
Jinfei YangDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, China.
Xuejing ZhuDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, China.
Li XiaoDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, China.
Lin SunDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endoplasmic reticulum (ER) is one of the most important cellular organelles and is essential for cell homeostasis. Upon external stimulation, ER stress induces the unfolded protein response (UPR) and ER-associated degradation (ERAD) to maintain ER homeostasis. However, persistent ER stress can lead to cell damage. ER-phagy is a selective form of autophagy that ensures the timely removal of damaged ER, thereby protecting cells from damage caused by excessive ER stress. As ER-phagy is a newly identified form of autophagy, many receptor-mediated ER-phagy pathways have been discovered in recent years. In this review, we summarize our understanding of the maintenance of ER homeostasis and describe the receptors identified to date. Finally, the relationships between ER-phagy and diseases are also discussed.

Indexed as

autophagyendoplasmic reticulum (ER)ERADER-phagyunfolded protein response (UPR)

Identifiers

PMID34307364
PMCPMC8299523
OpenAlexW3179377065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.