ReviewFrontiers in pediatrics2021
Splenomegaly in Children and Adolescents.
Review in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- A phase I/II study on intracerebroventricular tralesinidase alfa in patients with Sanfilippo syndrome type B.The Journal of clinical investigation · 2023Trial
- Clinical and Laboratory Indicators of Pediatric Leukemia and Neuroblastoma in Musculoskeletal Presentations: A Retrospective Study From a Resource-Limited Setting.European journal of haematology · 2026Article
- Organ size in small infants (The OSSI Study): establishing sonographic reference intervals for abdominal organs in preterm infants.European journal of pediatrics · 2026Article
- Transfer learning for Multi-institutional Classification of Intussusception and Splenomegaly in Pediatric Abdominal Radiographs.Journal of imaging informatics in medicine · 2026Article
- Evaluation of Splenic Volume and Surface Area According to Age and Gender: A Three-Dimensional Slicer Computed Tomography Study-Imaging.Diagnostics (Basel, Switzerland) · 2026Article
- Indeterminant Interferon-γ Release Assays in Refugee Children with Splenomegaly, Uganda, 2020-2023.Emerging infectious diseases · 2026Article
- A method for magnetic resonance splenomegaly image segmentation based on large-kernel multi-scale attention mechanism.Scientific reports · 2026Article
- A Study of the Clinico-Etiological Profile of Splenomegaly Among Children in a Tertiary Care Hospital.Cureus · 2025Article
- The impact of acute CMV coinfection on the course of EBV hepatitis in children.Clinical and experimental hepatology · 2025Article
- [Genetic and clinical characteristics of children withZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Study of Adult and Pediatric Spanish Patients with Cryptogenic Splenomegaly and Splenectomy.Diseases (Basel, Switzerland) · 2025Article
- Intrauterine blood transfusion causes dose- and time-dependent signal alterations in the liver and the spleen on fetal magnetic resonance imaging.European radiology · 2025Article
- Targeting the cholinergic anti-inflammatory pathway: an innovative strategy for treating diseases.Molecular biology reports · 2025Review
- Hereditary spherocytosis concomitant with JAK2V617F-positive primary myelofibrosis: a case report.Frontiers in oncology · 2025Article
- Immunosuppression of spleen in mice treated with erythropoietin: transcriptomic and immunological analysis.Frontiers in immunology · 2025Article
- Splenectomy at early stage of autoimmune arthritis delayed inflammatory response and reduced joint deterioration in mice.Clinical and experimental immunology · 2024Article
- Liver magnetic resonance elastography and fat fraction in pediatric patients with cystic fibrosis versus healthy children.Pediatric radiology · 2024Article
- Selection of surgical modality for massive splenomegaly in children.Surgical endoscopy · 2023Article
- Article
- The influence of steroid therapy of complications of infectious mononucleosis on the course of Epstein-Barr virus hepatitis.Clinical and experimental hepatology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to other lymphoid tissues making up the immune system, the spleen as its biggest organ is directly linked into the blood circulation. Beside its main task to filter out microorganism, proteins, and overaged or pathologically altered blood cells, also humoral and cellular immune responses are initiated in this organ. The spleen is not palpable during a physical examination in most but not all healthy patients. A correct diagnosis of splenomegaly in children and adolescents must take into account age-dependent size reference values. Ultrasound examination is nowadays used to measure the spleen size and to judge on reasons for morphological alterations in associated with an increase in organ size. An enormous amount of possible causes has to be put in consideration if splenomegaly is diagnosed. Among these are infectious agents, hematologic disorders, infiltrative diseases, hyperplasia of the white pulp, congestion, and changes in the composition and structure of the white pulp by immunologically mediated diseases. This review attempts to discuss a comprehensive list of differential diagnoses to be considered clinically in children and young adolescents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.