Evidence map›Paper›PMID 34307186›Full record

ArticleFrontiers in cellular and infection microbiology2021

Functional Polymorphisms in the p53 Pathway Genes on the Genetic Susceptibility to Zika Virus Teratogenesis.

Julia A Gomes, Eduarda Sgarioni, Igor A Vieira, Lucas R Fraga, Patrícia Ashton-Prolla, Ana Cláudia P Terças-Tretell, Juliana H da Silva, Bethânia F R Ribeiro, Marcial F Galera, Thalita M de Oliveira and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

Julia A GomesPrograma de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Eduarda SgarioniPrograma de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Igor A VieiraPrograma de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Lucas R FragaSistema Nacional de Informação sobre Agentes Teratogênicos (SIAT), Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
Patrícia Ashton-ProllaPrograma de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Ana Cláudia P Terças-TretellDepartamento de Enfermagem, Universidade do Estado de Mato Grosso (UNEMAT), Tangará da Serra, Brazil.
Juliana H da SilvaSecretaria Municipal de Saúde de Tangará da Serra, Tangará da Serra, Brazil.
Bethânia F R RibeiroFundação Hospital das Clínicas do Acre (FUNDACRE), Rio Branco, Brazil.
Marcial F GaleraDepartamento de Pediatria, Faculdade de Medicina, Universidade Federal de Mato Grosso (UFMT), Cuiabá, Brazil.
Thalita M de OliveiraHospital Universitário Júlio Müller (HUJM), Universidade Federal de Mato Grosso (UFMT), Cuiabá, Brazil.
Maria Denise F Carvalho de AndradeCurso de Medicina, Universidade Estadual do Ceará (UECE), Fortaleza, Brazil.
Isabella F CarvalhoCurso de Odontologia, Centro Universitário Christus (UNICHRISTUS), Fortaleza, Brazil.
Lavínia Schuler-FacciniPrograma de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Fernanda S L ViannaPrograma de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Universidade Federal do Rio Grande do Sul · BRHospital de Clínicas de Porto Alegre · BRUniversidade Federal de Mato Grosso · BRFundação de Tecnologia do Estado do Acre · BRNational Institute on Population Medical Genetics · BRSecretaria Municipal de Saúde · BRUnichristus · BRUniversidade do Estado de Mato Grosso · BRUniversidade Estadual do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital Zika Syndrome (CZS) occurs in up to 42% of individuals exposed to ZIKV prenatally. Deregulation in gene expression and protein levels of components of the p53 signaling pathway, such as p53 and MDM2, due to ZIKV infection has been reported. Here, we evaluate functional polymorphisms in genes of the p53 signaling pathway as risk factors to CZS. Forty children born with CZS and forty-eight children exposed to ZIKV, but born without congenital anomalies were included in this study. Gestational and sociodemographic information as well as the genotypic and allelic frequencies of functional polymorphisms in

Indexed as

MicroRNAsPregnancy Complications, InfectiousTeratogenesisZika VirusZika Virus InfectionChildFemaleGenetic Predisposition to DiseaseHumansPregnancyTumor Suppressor Protein p53MicroRNAsMIRN605 microRNA, humanTumor Suppressor Protein p53apoptosiscongenital abnormalitiesdisease susceptibilitygenetic polymorphismlissencephalyrisk factorsteratogensZika virus infection

Identifiers

PMID34307186
PMCPMC8294037
OpenAlexW3180513735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.