ArticleFrontiers in oncology2021
Comparison of a Tumor-Ratio-Metastasis Staging System and the 8th AJCC TNM Staging System for Gastric Cancer.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Efficacy and safety of disitamab vedotin (RC48) combined with camrelizumab and S-1 for neoadjuvant therapy of locally advanced gastric cancer with HER2-overexpressing: Preliminary results of a prospective, single-arm, phase II study.Clinical and translational medicine · 2026Trial
- Prognostic impact of lymph node ratio after suboptimal lymphadenectomy in gastric cancer: a retrospective cohort study with interaction analysis.World journal of surgical oncology · 2026Article
- Development of a machine learning-based model for predicting postoperative survival in gastric cancer.World journal of gastrointestinal surgery · 2026Article
- Histopathological subtypes and topographical subsites of gastric cancer in Sub-Saharan Africa: a scoping review.BMC cancer · 2026Article
- Machine learning-based reconstruction of prognostic staging for gastric cancer patients with different differentiation grades: A multicenter retrospective study.World journal of gastroenterology · 2025Article
- Comparison of prognostic accuracy of HCC staging systems in patients undergoing TACE.Clinical imaging · 2025Article
- Evaluation of three lymph node staging systems for prognostic prediction in gastric cancer: A systematic review and meta-analysis.World journal of gastrointestinal oncology · 2025Article
- Diagnostic value of systemic immune-inflammation index and prognostic nutritional index combined with CEA in gastric cancer with lymph node metastasis.Frontiers in endocrinology · 2025Article
- A prognostic nomogram for predicting overall survival in gastric signet ring cell carcinoma patients: a SEER database and Chinese registry analysis.Frontiers in molecular biosciences · 2025Article
- Application and progress of nomograms in gastric cancer.Frontiers in medicine · 2025Review
- Article
- A comprehensive radiopathological nomogram for the prediction of pathological staging in gastric cancer using CT-derived and WSI-based features.Translational oncology · 2024Article
- Clinical value of prognostic nutritional index combined with C-reactive protein and albumin in early prediction of anastomotic leakage after radical gastric cancer surgery.American journal of translational research · 2024Article
- A novel nomogram integrated with PDL1 and CEA to predict the prognosis of patients with gastric cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Article
- Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Article
- Anatomy and assessment of a modified technique during totally robotic distal gastrectomy: A retrospective cohort study.Annals of medicine and surgery (2012) · 2022Article
- Revisiting the 8th AJCC system for gastric cancer: A review on validations, nomograms, lymph nodes impact, and proposed modifications.Annals of medicine and surgery (2012) · 2022Review
- Short-term safety and Long-term efficacy of multivisceral resection in pT4b gastric cancer patients without distant metastasis: a 20-year experience in China National Cancer Center.Journal of Cancer · 2022Article
- A Pilot Study of Prognostic Value of Metastatic Lymph Node Count and Size in Patients with Different Stages of Gastric Carcinoma.Cancer management and research · 2022Article
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Abstract
backgroundDespite the implementation of the 8th American Joint Committee on Cancer (AJCC) TNM staging system for gastric cancer (GC) in 2017, it still holds a significant level of stage migration which affects patients' proper classification and accurate prognosis. Here, to reduce this effect, we evaluated the prognostic value of a lymph node ratio (LNR) and established a novel tumor-ratio-metastasis (TRM) staging system.
methodThe data of 15,206 GC patients from the Sun Yat-sen University Cancer Center (Training set; n=2,032) and the US Surveillance, Epidemiology, and End Results (SEER) database (Validation set; n=13,174) were analyzed. The training set was classified into 5 LNR categories, based on which the novel TRM staging system was constructed. The overall survival (OS) between the TRM and AJCC TNM systems was compared in the training set and validated in the validation set. The likelihood ratio
resultThe patients were classified into the following categories: LNR0: 0%, LNR1: 0%<LNR ≤ 10%, LNR2: 10%<LNR ≤ 25%, LNR 3a: 25%<LNR ≤ 60%, and LNR 3b: LNR>60%. Univariate analyses demonstrated that the log-rank
conclusionThe TRM staging system demonstrated improved homogeneity and discriminatory ability in predicting the prognosis of GC patients compared with the AJCC TNM staging system.
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