Evidence map›Paper›PMID 34306964›Full record

ReviewCurrent addiction reports2021

Mothering from the Inside Out: Addressing the Intersection of Addiction, Adversity, and Attachment with Evidence-Based Parenting Intervention.

Amanda F Lowell, Elizabeth Peacock-Chambers, Amanda Zayde, Cindy L DeCoste, Thomas J McMahon, Nancy E Suchman

2 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in Current addiction reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07168642 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Type I Hybrid Effectiveness-Implementation Trial of Mothering From the Inside Out (MIO)

TypeinterventionalSponsorBaystate Medical CenterRan2025 to 2029Enrolled200ConditionsSubstance Use DisorderArmsMothering from the Inside Out
NCT07743359 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Relational Health Enhanced Parenting Support (RHEP) Type 2 Hybrid Effectiveness-Implementation Study

TypeinterventionalSponsorBaystate Medical CenterRan2026 to 2030Enrolled288ConditionsSubstance Use Disorders (SUDs)ArmsRelational Health Enhanced Parenting Support (RHEP) implementation bundle, First Steps Together
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. A randomized controlled trial to improve fathering among fathers with substance use disorders: Fathering in recovery intervention.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2023
    Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Amanda F LowellYale Child Study Center, Yale School of Medicine, 230 South Frontage Road, New Haven, CT 06520 USA.ORCID 0000-0002-6558-8736
Elizabeth Peacock-ChambersDepartment of Pediatrics, University of Massachusetts Medical School-Baystate, Springfield, MA USA.
Amanda ZaydeMontefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY USA.
Cindy L DeCosteYale Department of Psychiatry, Yale School of Medicine, New Haven, CT USA.
Thomas J McMahonYale Child Study Center, Yale School of Medicine, 230 South Frontage Road, New Haven, CT 06520 USA.
Nancy E SuchmanYale Child Study Center, Yale School of Medicine, 230 South Frontage Road, New Haven, CT 06520 USA.
Yale University · USAlbert Einstein College of Medicine · USBaystate Medical Center · US

Funding

Tufts Clinical and Translational Science Institute (Pilot Supplement)UL1TR002544 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2018 to 2022
$50.2M
University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI Lane Strathearn · 2021 to 2026
$8.5M
Oxytocin and Brain Reward and Stress Responses to Infant Cues in Addicted MothersR01DA026437 · NIDA · UNIVERSITY OF IOWA · PI MAYES, LINDA CAROL, STRATHEARN, LANE · 2010 to 2020
$7.2M
Fostering Mothers'Emotionally-Responsive ParentingR01DA017294 · NIDA · YALE UNIVERSITY · PI MCMAHON, THOMAS J · 2004 to 2019
$6.0M
University of Massachusetts Center for Clinical and Translational ScienceKL2TR001455 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIEFE, CATARINA I. · 2015 to 2024
$5.0M
A Multimodal Parent-focused Intervention for Vulnerable Populations in the BronxR01MH126821 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI ALPERT, JONATHAN EDWARD, GABBAY, VILMA · 2021 to 2025
$4.2M
Psychosocial and neurobiological stress and opioid use trajectories following pregnancyR01DA050636 · NIDA · YALE UNIVERSITY · PI RUTHERFORD, HELENA JV, YIP, SARAH · 2020 to 2024
$2.8M
Neural mechanisms of galantamine treatment for cocaine dependenceK01DA039299 · NIDA · YALE UNIVERSITY · PI YIP, SARAH · 2016 to 2020
$905k
NCATS NIH HHS KL2 TR001455NCATS NIH HHS UL1 TR002544NICHD NIH HHS P50 HD103556NIDA NIH HHS K01 DA039299NIDA NIH HHS R01 DA017294NIDA NIH HHS R01 DA026437NIDA NIH HHS R01 DA050636NIMH NIH HHS R01 MH126821
6 · The paper itself

Abstract

Purpose of Review: Mothers with substance use disorders are often referred for parenting support, though commonly available programs may miss the mark for families impacted by addiction. This may be related to a lack of attention to children's emotional needs, mothers' histories of adversity, and the neurobiological differences seen in mothers with addictions. We review the implications of addiction, adversity, and attachment for parenting interventions. We then describe Mothering from the Inside Out (MIO), an evidence-based parenting intervention designed specifically for mothers with addictions. Recent Findings: Evidence from clinical trials suggests that MIO improves outcomes for two generations: both mothers with addictions and their children. Recent trials demonstrate that MIO may be delivered effectively by community-based clinicians and may be beneficial for parents with other chronic stressors. Summary: Addressing addiction, adversity, and attachment simultaneously may have a positive synergistic effect. Future research should study the implementation of MIO in real-world settings and examine the impact of MIO on maternal neurobiology.

Indexed as

AttachmentChildhood adversityEvidence-based treatmentMaternal substance useMentalizationReflective functioning

Identifiers

PMID34306964
PMCPMC8280593
OpenAlexW3184867198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.