Evidence map›Paper›PMID 34306804›Full record

ArticleACS catalysis2020

Single-step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in Anaerobic Ergothioneine Biosynthesis.

Ronghai Cheng, Lian Wu, Rui Lai, Chao Peng, Nathchar Naowarojna, Weiyao Hu, Xinhao Li, Stephen A Whelan, Norman Lee, Juan Lopez and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  12. How to Stabilize Carbenes in Enzyme Active Sites without Metal Ions.Journal of the American Chemical Society · 2022
    Article
  13. Article
  14. Review
  15. OvoAChemical science · 2022
    Article
  16. Article
  17. Article
  18. Sulfur incorporation into biomolecules: recent advances.Critical reviews in biochemistry and molecular biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Ronghai ChengDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Lian WuState Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai 200032, China.
Rui LaiDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Chao PengNational Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China.
Nathchar NaowarojnaDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Weiyao HuDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Xinhao LiSchool of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Stephen A WhelanDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Norman LeeDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Juan LopezDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Changming ZhaoDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Youhua YongState Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai 200032, China.
Jiahui XueShanghai Key Laboratory of Green Chemistry and Chemical Process, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, P. R. China.
Xuefeng JiangShanghai Key Laboratory of Green Chemistry and Chemical Process, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, P. R. China.
Mark W GrinstaffDepartment of Chemistry, Boston University, Boston, MA 02215, USA.ORCID 0000-0002-5453-3668
Zixin DengKey Laboratory of Combinatory Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Hubei 430072, People's Republic of China.
Jiesheng ChenSchool of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Qiang CuiDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Jiahai ZhouState Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai 200032, China.
Pinghua LiuDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Boston University · USChinese Academy of Sciences · CNEast China Normal University · CNShanghai Jiao Tong University · CNShanghai Advanced Research Institute · CNWuhan University · CN

Funding

Development and application of QM/MM methods for metalloenzymesR01GM106443 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI CUI, QIANG · 2013 to 2020
$2.3M
Production Scale-Up and Target Identification of the Antioxidant ErgothioneineR41AT010878 · NCCIH · ERGO HEALTH, LLC · PI LIU, PINGHUA · 2019 to 2020
$225k
NCCIH NIH HHS R41 AT010878NIGMS NIH HHS R01 GM106443
6 · The paper itself

Abstract

Ergothioneine, a natural longevity vitamin and antioxidant, is a thiol-histidine derivative. Recently, two types of biosynthetic pathways were reported. In the aerobic ergothioneine biosynthesis, a non-heme iron enzyme incorporates a sulfoxide to an sp

Indexed as

C-H bond activationcrystal structureergothioneine biosynthesispolysulfidetranssulfuration

Identifiers

PMID34306804
PMCPMC8302205
OpenAlexW3042344159

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.