ReviewJournal of ophthalmology2021
New Horizons in the Treatment of Corneal Endothelial Dysfunction.
Review in Journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Air/gas migration after descemet membrane endothelial keratoplasty (DMEK): the impact of scleral-fixated versus posterior chamber intraocular lenses.BMC ophthalmology · 2026Article
- Injectable corneal endothelial cell therapy: recent progress, translational barriers, and future directions.Frontiers in ophthalmology · 2026Review
- Tomographic Differences in Thin Corneas Following DMEK in Fuchs Dystrophy: A Case-Control Study.Ophthalmology and therapy · 2026Article
- Case report of spontaneous corneal clearance after subtotal graft detachment following combined Descemet's membrane endothelial keratoplasty and cataract surgery.American journal of ophthalmology case reports · 2025Article
- Endothelial keratoplasty: indications and outcomes in a tertiary care center in Lebanon.BMC ophthalmology · 2025Article
- Preoperative edema severity affects outcomes after Descemet membrane endothelial keratoplasty for Fuchs endothelial corneal dystrophy: a cohort study.Eye and vision (London, England) · 2025Article
- Graft-repositioning technique using infusion and small bubbles during Descemet's membrane endothelial keratoplasty.BMC ophthalmology · 2025Article
- Long-term outcomes of corneal transplantation: a review of 8,378 patients.BMC ophthalmology · 2025Article
- Posterior Limbal Mesenchymal Stromal Cells Promote Proliferation and Stemness of Transition Zone Cells: A Novel Insight Into Corneal Endothelial Rejuvenation.Investigative ophthalmology & visual science · 2025Article
- Evolving indications and surgical techniques for corneal transplantation at a tertiary eye care center in southern China.BMC ophthalmology · 2024Article
- The Protective Effect of Rho-Associated Kinase Inhibitor Eye Drops (Ripasudil) on Corneal Endothelial Cells After Cataract Surgery: A Prospective Comparative Study.Ophthalmology and therapy · 2024Article
- Fuchs endothelial corneal dystrophy: an updated review.International ophthalmology · 2024Review
- Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure.Frontiers in bioengineering and biotechnology · 2024Review
- Descemet Stripping Automated Endothelial Keratoplasty in Thick Corneas.Journal of clinical medicine · 2022Article
- The Descemet Membrane Endothelial Keratoplasty (DMEK) "Wave Maneuver".Journal of clinical medicine · 2022Article
- Evaluation of corneal nerves and dendritic cells by in vivo confocal microscopy after Descemet's membrane keratoplasty for bullous keratopathy.Scientific reports · 2022Article
- Cost Burden of Endothelial Keratoplasty in Fuchs Endothelial Dystrophy: Real-World Analysis of a Commercially Insured US Population (2014-2019).Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Vision through Healthy Aging Eyes.Vision (Basel, Switzerland) · 2021Review
- Corneal Subbasal Plexus in Eyes with Fuchs' Endothelial Corneal Dystrophy after Two Different Endothelial Surgeries.Journal of ophthalmology · 2021Article
- "Anterior Chamber Diaphragm": A Temporary Device to Make Corneal Endothelial Cell Therapy Safe!Journal of current ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment of corneal endothelial dysfunction has experienced a revolutionary change in the past decades with the emergence of endothelial keratoplasty techniques: descemet stripping automated endothelial keratoplasty (DSAEK) and descemet membrane endothelial keratoplasty (DMEK). Recently, new treatments such as cultivated endothelial cell therapy, Rho-kinase inhibitors (ROCK inhibitors), bioengineered grafts, and gene therapy have been described. These techniques represent new lines of treatment for endothelial dysfunction. Their advantages are to help address the shortage of quality endothelial tissue, decrease the complications associated with tissue rejection, and reduce the burden of postoperative care following transplantation. Although further randomized clinical trials are required to validate these findings and prove the long-term efficacy of the treatments, the positive outcomes in preliminary clinical studies are a stepping stone to a promising future. Our aim is to review the latest available alternatives and advancements to endothelial corneal transplant.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.