Evidence map›Paper›PMID 34306495›Full record

ArticleAmerican journal of translational research2021

The predictive value of microRNA in early hypertensive disorder complicating pregnancy (HDCP).

Yan Jin, Tingting Jia, Xueling Wu, Yanyan Wang, Wenwen Sun, Yajun Chen, Guimei Wu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Changes in microRNA expression associated with preeclampsia: a systematic review.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Pooled it
  3. Blood Pressure and Late Pregnancy Circulating miRNAs in the MADRES Study.Journal of the American Heart Association · 2025
    Article
  4. Article
  5. MicroRNA-181 in cardiovascular disease: Emerging biomarkers and therapeutic targets.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yan JinObstetrics Department I, Cangzhou Central Hospital Cangzhou, China.
Tingting JiaObstetrics Department I, Cangzhou Central Hospital Cangzhou, China.
Xueling WuObstetrics Department I, Cangzhou Central Hospital Cangzhou, China.
Yanyan WangObstetrics Department I, Cangzhou Central Hospital Cangzhou, China.
Wenwen SunObstetrics Department I, Cangzhou Central Hospital Cangzhou, China.
Yajun ChenObstetrics Department I, Cangzhou Central Hospital Cangzhou, China.
Guimei WuObstetrics Department III, Cangzhou Central Hospital Cangzhou, China.
Cangzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the predictive value of microRNA (miRNA) in hypertensive disorder complicating pregnancy (HDCP).

methods102 pregnant women with HDCP admitted to our hospital from March 2017 to June 2019 were recruited as the study cohort and randomly divided into an HDCP group, a mild preeclampsia group, and a severe preeclampsia group, with 34 patients in each group. In addition, 34 healthy pregnant women who underwent pregnancy tests in our hospital were recruited as the normal group. The relative expressions of plasma miR-19a, miR-126, and miRNA-210 in were measured. A Pearson correlation analysis was used to analyze the correlations between the miR-19a, miR-181b, and miRNA-210 expressions and the severity of HDCP. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy of the miR-19a, miR-126, and miRNA-210 expressions.

resultsThe miR-19a and miRNA-210 expressions were higher in the HDCP group, the mild preeclampsia group, and the severe preeclampsia group than they were in the normal group, and the miR-126 expression was lower (all P<0.05). The miR-19a, miR-126, and miRNA-210 expressions were different among the four groups (P<0.05). The miR-19a and miRNA-210 expression levels in the severe preeclampsia group were higher than they were in the HDCP group, and the miR-126 expression was lower (P<0.05). A Pearson correlation analysis showed the miR-19a and miR-210 levels in the HDCP patients were positively correlated with the severity of the disease (P<0.05), and the miR-126 level is negatively correlated with disease severity (P<0.05). Our ROC curve analysis demonstrated that the miR-19a, miR-126, and miR-210 levels have a predictive value for HDCP. The areas under the curve were 0.800, 0.633, and 0.723, the sensitivities were 81.2%, 71.4%, and 80.2%, and the specificities were 73.5%, 67.5%, 81.5%. Additionally, the area under the curve of the combination of the three was 0.896, and the sensitivity and specificity were 90.5% and 93.9% respectively.

conclusionmiR-19a, miR-126, and miR-210 are strongly connected to the severity of HDCP and can be used as a sensitive indicator to predict HDCP patients clinically.

Indexed as

hypertension during pregnancyMicroRNApre-eclampsia

Identifiers

PMID34306495
PMCPMC8290685
OpenAlexW3186810370

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.