Evidence map›Paper›PMID 34306492›Full record

ArticleAmerican journal of translational research2021

Curative effects of montmorillonite powder combined with dexamethasone on acute radiation enteritis.

Wenping Chen, Qiaoling Ma, Limin Yang, Lei Zhang, Jiandong Zhu, Wanlin Lin

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06410443 (Efficacy and Safety of Local Glucocorticoids for the Treatment of Acute Radiation-Induced Intestinal Injury), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06410443 narecruitingnot on this mapstarted 2024, after this paper: background citation

Efficacy and Safety of Local Glucocorticoids for the Treatment of Acute Radiation-Induced Intestinal Injury: A Randomized Controlled Trial

TypeinterventionalSponsorGeneral Hospital of Shenyang Military RegionRan2024 to 2026Enrolled60ConditionsRadiation-Induced Intestinal InjuryArmsDexamethasone, Antibiotics, probiotics, vitamins, antidiarrheal drugs, enteral nutrition, and endoscopic argon plasma coagulation
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Mechanism of action of montmorillonite powder on injury and repair factors in Stage II pressure ulcers in model mice.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wenping ChenDepartment of Pelvic Anorectal Surgery, Xi'an Daxing Hospital Xi'an, Shaanxi Province, China.
Qiaoling MaDepartment of Pelvic Anorectal Surgery, Xi'an Daxing Hospital Xi'an, Shaanxi Province, China.
Limin YangDepartment of Pelvic Anorectal Surgery, Xi'an Daxing Hospital Xi'an, Shaanxi Province, China.
Lei ZhangDepartment of Pelvic Anorectal Surgery, Xi'an Daxing Hospital Xi'an, Shaanxi Province, China.
Jiandong ZhuDepartment of Pelvic Anorectal Surgery, Xi'an Daxing Hospital Xi'an, Shaanxi Province, China.
Wanlin LinDepartment of Pelvic Anorectal Surgery, Xi'an Daxing Hospital Xi'an, Shaanxi Province, China.
Shenyang Anorectal Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the curative effects of montmorillonite powder combined with dexamethasone on acute radiation enteritis.

methodsEighty-six patients with acute radiation enteritis were enrolled in this prospective research, and they were divided into a control group and an intervention group using a random number table, with 43 cases in each group. Patients in both groups received conventional treatment. The control group was treated with montmorillonite powder, and the intervention group was treated with retention enema with dexamethasone based on montmorillonite powder. The grades of mucosal damage, changes in cytokine levels, the efficacy of colonoscopy, and overall curative effects of the two groups before and after treatment were observed.

resultsAfter treatment, the levels of IL-2 and IFN-γ of the two groups were significantly reduced, and the level of IL-10 was significantly increased. The intervention group was significantly better than the control group (all P<0.001). The grades of mucosal damage in the intervention group showed better improvement than that in the control group (P<0.01), and the overall curative effects in the intervention group were significantly better than those in the control group (both P<0.05).

conclusionMontmorillonite powder combined with dexamethasone is effective in treating patients with acute radiation enteritis, which can effectively alleviate mucosal damage, improve inflammation, and promote patient recovery. It has the value of promotion and application.

Indexed as

acute radiation enteritiscurative effectdexamethasoneMontmorillonite powder

Identifiers

PMID34306492
PMCPMC8290743
OpenAlexW3186573422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.