Evidence map›Paper›PMID 34306468›Full record

ArticleAmerican journal of translational research2021

MTHFR gene polymorphism and homocysteine levels in spontaneous abortion of pregnant women.

Linjing Zhang, Hainei Fu, Tao Wei

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Linjing ZhangDepartment of Obstetrics and Gynecology, Hainan Province Women and Children Medical Center Haikou, Hainan Province, China.
Hainei FuDepartment of Obstetrics and Gynecology, Hainan Province Women and Children Medical Center Haikou, Hainan Province, China.
Tao WeiLibrary, Kunming Medical University Kunming, Yunnan Province, China.
Hainan Modern Women and Children's Hospital · CNKunming Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis research explored the expression of MTHFR gene polymorphism and homocysteine (Hcy) in spontaneous abortions in pregnant women.

methodsEighty-two spontaneous abortion patients treated in our hospital were selected prospectively, and 82 age-matched healthy and normal delivery women were included. The peripheral venous blood of the two groups was obtained, and the differences between MTHFR gene polymorphism and Hcy levels were analyzed.

resultsThe Hcy levels in spontaneous abortion patients were higher than those in the healthy control group (P<0.05). In the common mutation (C677T) of MTHFR gene polymorphism, the distribution of MTHFRC677T (TT, CC, CT) genotyping of both groups was different, but the Hcy levels in the observation group were higher than those in the normal control group (P<0.05). In addition, logistic analysis manifested that the the Hcy levels were higher than normal and MTHFRC677T (TT) mutant was an independent risk factor for spontaneous abortion of pregnant women.

conclusionMTHFRC677T (TT) is associated with the occurrence of hyperhomocysteinemia, and its high expression often indicates that the risk of spontaneous abortion is greatly increased, which may provide a new research direction for maternal health.

Indexed as

gene polymorphismHcy levelsMTHFRC677Tpregnant womanSpontaneous abortion

Identifiers

PMID34306468
PMCPMC8290815
OpenAlexW3185454669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.