ArticleAmerican journal of translational research2021
Significance of TRPV5 and OPN biomarker levels in clinical diagnosis of patients with early urinary calculi.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Article
- Urinary adhesion molecules with ERK signaling as predictive biomarkers for kidney stones: a pilot study.BMC urology · 2026Article
- CT-based radiomics of machine-learning to screen high-risk individuals with kidney stones.Urolithiasis · 2024Article
- Osteopontin-A Potential Biomarker for IgA Nephropathy: Machine Learning Application.Biomedicines · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the clinical significance of the expression levels of transient receptor potential vanilloid 5 (TRPV5) and Osteopontin (OPN) biomarkers for the diagnosis of early-stage urinary stones.
methodsA total of 48 calcium-containing kidney stone patients admitted to our hospital between February 2018 and February 2019 were selected as the experimental group in this study, and another 48 age-matched stone-free healthy individuals were selected as the control group, and the expression levels of TRPV5 and OPN biomarkers in the two groups were examined and compared with respect to related indicators.
resultsThe urine oxalic acid content of the experimental group was found to be notably higher than the control group, while the citric acid content was lower; we observed higher levels of the 24-hour urine calcium content in the experimental group, while the citric acid/calcium ratio was remarkably lower; 24-hour urine magnesium and phosphorus levels of the two groups showed no marked difference; the mRNA expression levels of TRPV5 and OPN in the kidney tissues of the two groups were statistically different.
conclusionThe level of TRPV5 in urinary calculi patients was found to be significantly lower, whereas the level of OPN was significantly higher than the normal control, thus TRPV5 and OPN biomarker levels can be used as diagnostic markers for early urinary calculi.
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34306426PMC8290816W3185114656What OpenQuestion holds
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