ArticleAmerican journal of translational research2021
Effects of ginkgo diterpene lactone on brain inflammation and oxidative stress in rats with cognitive impairment of cerebral small vessel disease.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Research progress of traditional Chinese medicine interventions for aging-related nervous system diseases.Biogerontology · 2026Review
- Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment.International journal of molecular medicine · 2026Article
- Superoxide dismutase is associated with cerebral small vessel disease burden and vascular mild cognitive impairment in elderly patients.Frontiers in neuroscience · 2025Article
- Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke.Open medicine (Warsaw, Poland) · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aims to investigate the effects of ginkgo diterpene lactone on brain inflammation and oxidative stress in rats with cognitive impairment of cerebral small vessel disease (CSVD).
methodsWe equally assigned 40 Sprague Dawley (SD) rats to the observation group (OG) and the control group (CG) and modeled them for cognitive impairment of CSVD. Rats in OG were given ginkgo diterpene lactone for treatment, while those in CG were injected with the same amount of normal saline. The learning and memorizing ability of rats was tested by the water maze. The oxidative stress and inflammatory response in rats were evaluated. The levels of vascular endothelial growth factor (VEGF) and endostatin (ES) mRNA in the hippocampus of rats were measured. Vascular smooth muscle cells of rats were sampled for cell viability and apoptosis assays.
resultsRats from OG were superior to those from CG in the learning and memorizing ability. After treatment, rats from OG had markedly lower malondialdehyde (MDA) levels and higher levels of superoxide dismutase (SOD), reduced glutathione (GSH), and glutathione peroxidase (GSH-Px) than those from CG (all
conclusionGinkgo diterpene lactone can inhibit oxidative stress and inflammatory response in rats with cognitive impairment of CSVD to a certain degree.
Indexed as
Identifiers
34306377PMC8290712W3186508805What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.