ArticleAmerican journal of translational research2021
Circ_0057452 functions as a ceRNA in hypertrophic scar fibroblast proliferation and VEGF expression by regulating TGF-β2 expression and adsorbing miR-145-5p.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 4 citations in OpenAlex.
- Exploring the Complexities of TGF-β Signaling in Keloids: Beyond the Classical Smad Pathway.International journal of molecular sciences · 2026Review
- Exosome-Loaded GelMA Hydrogel as a Cell-Free Therapeutic Strategy for Hypertrophic Scar Inhibition.Clinical, cosmetic and investigational dermatology · 2025Article
- A shikonin-based hydrogel dressing exhibiting synergistic anti-inflammatory, anti-angiogenic, and anti-fibrotic effects for the prevention of hypertrophic scars.Frontiers in immunology · 2025Article
- Exosomal miR‑194 from adipose‑derived stem cells impedes hypertrophic scar formation through targeting TGF‑β1.Molecular medicine reports · 2024Article
- Expression of macrophage activation‑specific factors in hyperplastic scar tissue during hyperplasia phase by antibody array blotting membrane assay and its clinical significance.Experimental and therapeutic medicine · 2024Article
- P-MSC-derived extracellular vesicles facilitate diabetic wound healing via miR-145-5p/ CDKN1A-mediated functional improvements of high glucose-induced senescent fibroblasts.Burns & trauma · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the mechanism by which circ_0057452/miR-145-5p/TGF-β2 axis regulates fibroblast proliferation as well as VEGF expression in hypertrophic scars (HS).
methodsThe expression of circ_0057452, miR-145-5p and TGF-β2 in HS tissues and fibroblasts was measured by quantitative real-time Polymerase Chain Reaction (qRT-PCR). The targeting relations between circ_0057452 and miR-145-5p, miR-145-5p and TGF-β2 were identified using dual-luciferase reporter assay. The expression of circ_0057452, miR-145-5p and TGF-β2 in fibroblasts was interfered with and cells were grouped. In each group, changes in cell proliferation were detected using CCK8 assay, apoptosis was measured by flow cytometry, and VEGF secreted in cell culture supernatant was tested by ELISA kit.
resultsCompared with normal tissues and fibroblasts, the expressions of circ_0057452 and TGF-β2 were increased and miR-145-5p decreased in HS tissues and cells (all P<0.05). Compared with the si-NC group, cell proliferation and VEGF expressions were decreased and the apoptotic rate increased in the si_circ_0057452 group (all P<0.05). Compared with the oe-NC group, cell proliferation and VEGF expression were increased and the apoptotic rate decreased in the oe-circ_0057452 group (all P<0.05). Compared with the oe-circ_0057452 + miR-NC group, the number of apoptotic cells was increased, and cell proliferation, as well as VEGF expression were decreased in the oe-circ_0057452 + miR-145-5p mimic group (all P<0.05). Compared with the miR-NC group, cell proliferation and VEGF expression were reduced and the apoptotic rate was increased in the miR-145-5p mimic group (all P<0.05). Compared with the miR-145-5p mimic + vector group, cell proliferation and VEGF expression were elevated, and apoptosis was inhibited in the miR-145-5p mimic + TGF-β2 group (all P<0.05).
conclusioncirc_0057452 can competitively bind miR-145-5p to induce the expression of TGF-β2, and then promote the proliferation of HS fibroblasts and secretion of VEGF, which is expected to be effective in the treatment of HS.
Indexed as
Identifiers
34306359PMC8290727W3185801752What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.