Evidence map›Paper›PMID 34306335›Full record

ArticleAmerican journal of translational research2021

Effect of mesenchymal stem cells combined with chondroitin sulfate in an

Saúl Pérez-Castrillo, Maria Luisa González-Fernández, Jessica Álvarez-Suárez, Jaime Sánchez-Lázaro, Marta Esteban-Blanco, Laura Gutiérrez-Velasco, Elsa González-Cubero, Vega Villar-Suárez

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. [Research progress of infrapatellar fat pad derived mesenchymal stem cells in treatment of osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Saúl Pérez-CastrilloDepartment of Anatomy, Faculty of Veterinary Sciences, Campus de Vegazana, University of Léon-Universidad de León León 24071, Spain.
Maria Luisa González-FernándezDepartment of Anatomy, Faculty of Veterinary Sciences, Campus de Vegazana, University of Léon-Universidad de León León 24071, Spain.
Jessica Álvarez-SuárezDepartment of Anatomy, Faculty of Veterinary Sciences, Campus de Vegazana, University of Léon-Universidad de León León 24071, Spain.
Jaime Sánchez-LázaroInstitute of Biomedicine (IBIOMED), Faculty of Veterinary Sciences, Campus de Vegazana, University of León-Universidad de León León 24071, Spain.
Marta Esteban-BlancoDepartment of Anatomy, Faculty of Veterinary Sciences, Campus de Vegazana, University of Léon-Universidad de León León 24071, Spain.
Laura Gutiérrez-VelascoDepartment of Anatomy, Faculty of Veterinary Sciences, Campus de Vegazana, University of Léon-Universidad de León León 24071, Spain.
Elsa González-CuberoDepartment of Anatomy, Faculty of Veterinary Sciences, Campus de Vegazana, University of Léon-Universidad de León León 24071, Spain.
Vega Villar-SuárezDepartment of Anatomy, Faculty of Veterinary Sciences, Campus de Vegazana, University of Léon-Universidad de León León 24071, Spain.
Universidad de León · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a degenerative joint disease affecting the whole joint structure. The specific molecules responsible for the inflammatory processes involved in the development of OA have been the focus of many studies. Adipose tissue-derived mesenchymal stem cells (ASCs) constitute a promising cell-based therapy which could be used as an alternative to or in combination with drug therapies. Chondroitin sulfate (CS) plays a protective role in the joint by decreasing concentrations of pro-inflammatory cytokines and therefore has an important part in moderating chondrocyte metabolism. The aim of this study is to use an

Indexed as

chondroitin sulfateMesenchymal stem cellsosteoarthritis

Identifiers

PMID34306335
PMCPMC8290715
OpenAlexW3183748521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.