ReviewAmerican journal of translational research2021
Pineal region tumors: pathophysiological mechanisms of presenting symptoms.
Review in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Multimodal clinical-radiomic-deep learning model for preoperative classification of pediatric pineal region tumors.Neuroradiology · 2026Article
- Neurosurgical management of pineal lesions: Insights from a single-center study of 27 cases.BioMedicine · 2026Article
- Hydrocephalus Secondary to Pineal Region Lesions.Advances and technical standards in neurosurgery · 2026Review
- Pineal Gland Parenchyma Tumors.Advances and technical standards in neurosurgery · 2026Review
- How is rosette formation in brain tumours linked with cerebrospinal fluid spread?Brain tumor pathology · 2026Review
- Clinico-radiological Analysis and outcomes of management of pineal region space occupying lesions: A multi-departmental, retrospective case series from Pakistan.Pakistan journal of medical sciences · 2025Article
- Supracerebellar highway-fast and safe road to pediatric pineal tumor resection.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- A rare case of pineal astrocytoma with hemorrhagic changes: Diagnostic and surgical challenges.Radiology case reports · 2025Article
- The surgical intervention for pineal region tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Pediatric Pineal Region Tumors: Special Reference to Posterior Interhemispheric Trans-Tentorial Approach.Advances and technical standards in neurosurgery · 2023Review
- Combined supracerebellar infratentorial and right occipital interhemispheric approach to falcotentorial junction meningioma: A case report.Surgical neurology international · 2023Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pineal region tumors (PRTs) affect all ages, with a remarkable proportion of cases occurring in children. They are mainly classified into three categories, namely germ cell tumors (GCTs), pineal parenchymal tumors (PPTs), and other tumors such as gliomas and tumors of the surrounding structures. The purpose of this article is to review the current literature regarding pathophysiological mechanisms of the presenting clinical features of patients with PRT. The usual presentation of PRTs is the symptoms of obstructive hydrocephalus and intracranial hypertension, such as headache and vomiting. However, there is a remarkable spectrum of clinical findings that can be caused by such lesions. These include ophthalmologic and endocrinologic disturbances, motor and sensory abnormalities, and cognitive and psychiatric symptoms. The unique anatomic location of the pineal gland, which is close to many vital brain structures, is crucial for the explanation of most of those findings. In rare cases, manifestations of intracranial bleeding may be the presenting feature of a PRT. Tumor histology and patient's age can affect the clinical presentation. Hydrocephalus is the most common clinical syndrome of a PRT because of the location of the pineal gland. Presenting symptoms also include ophthalmologic, endocrinologic, motor, sensory, cognitive, and psychiatric symptoms. Clinicians should be aware of the initial symptoms of PRTs, including the misleading ones, in order to avoid delay in the diagnosis and management of these life-threatening lesions.
Indexed as
Identifiers
34306324PMC8290707W3185720563What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.